Abstract
The vascular compartment of the adult neurogenic niche is a major regulatory hub for neural stem cells. Here, Kokovay and colleagues show that the chemokine SDF1 is expressed by a subset of the blood vessels within the niche associated with proliferating progenitors. Knockdown of the SDF1 receptor leads to aberrant lineage progression.
Original language | English (US) |
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Pages (from-to) | 6-13 |
Number of pages | 8 |
Journal | Stem Cell Reports |
Volume | 12 |
Issue number | 1 |
DOIs | |
State | Published - Jan 8 2019 |
Keywords
- CXCL14
- CXCR4
- SDF1
- blood vessels
- neural stem cells
- niche
- vasculature
ASJC Scopus subject areas
- Genetics
- Biochemistry
- Cell Biology
- Developmental Biology