Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche

Chang Zhu; Swetha Mahesula; Sally Temple; Erzsebet Kokovay

doi:10.1016/j.stemcr.2018.11.022

Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche

Chang Zhu, Swetha Mahesula, Sally Temple, Erzsebet Kokovay

Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The vascular compartment of the adult neurogenic niche is a major regulatory hub for neural stem cells. Here, Kokovay and colleagues show that the chemokine SDF1 is expressed by a subset of the blood vessels within the niche associated with proliferating progenitors. Knockdown of the SDF1 receptor leads to aberrant lineage progression.

Original language	English (US)
Pages (from-to)	6-13
Number of pages	8
Journal	Stem Cell Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/j.stemcr.2018.11.022
State	Published - Jan 8 2019

Keywords

CXCL14
CXCR4
SDF1
blood vessels
neural stem cells
niche
vasculature

ASJC Scopus subject areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

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abstract = "The vascular compartment of the adult neurogenic niche is a major regulatory hub for neural stem cells. Here, Kokovay and colleagues show that the chemokine SDF1 is expressed by a subset of the blood vessels within the niche associated with proliferating progenitors. Knockdown of the SDF1 receptor leads to aberrant lineage progression.",

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