Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche

Chang Zhu, Swetha Mahesula, Sally Temple, Erzsebet Kokovay

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The vascular compartment of the adult neurogenic niche is a major regulatory hub for neural stem cells. Here, Kokovay and colleagues show that the chemokine SDF1 is expressed by a subset of the blood vessels within the niche associated with proliferating progenitors. Knockdown of the SDF1 receptor leads to aberrant lineage progression.

Original languageEnglish (US)
Pages (from-to)6-13
Number of pages8
JournalStem Cell Reports
Volume12
Issue number1
DOIs
StatePublished - Jan 8 2019

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Keywords

  • CXCL14
  • CXCR4
  • SDF1
  • blood vessels
  • neural stem cells
  • niche
  • vasculature

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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