Heritability of obesity-related traits among Nigerians, Jamaicans and US black people

A. Luke, X. Guo, A. A. Adeyemo, R. Wilks, T. Forrester, W. Lowe, A. G. Comuzzie, L. J. Martin, X. Zhu, C. N. Rotimi, R. S. Cooper

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

OBJECTIVE: The mean values for anthropometric traits vary across population groups and this variation is clearly determined for the most part by the environment. The familiarity of anthropometric traits also varies in reports from different populations, although this variation has not been shown to follow a consistent pattern. To examine whether heritability is influenced by socio-cultural factors, we conducted a cross-cultural study of populations of the African diaspora. PARTICIPANTS: Data were collected on 1868 family members from Nigeria, 623 from Jamaica and 2132 from metropolitan Chicago, IL, USA. MEASUREMENTS: Height and weight were measured and body mass index (kg/m2) calculated. Fat-free mass, fat mass and percentage body fat were estimated using bioelectrical impedance analysis. Plasma leptin concentrations were also measured. The proportion of variance attributable to additive genetic and non-shared environmental components was estimated with the maximum likelihood variance decomposition method. RESULTS: Mean values for all anthropometric traits increased along the socio-cultural gradient, and obesity increased from 5% in Nigeria to 23% in Jamaica and 39% in the USA. Within populations the relationships among traits both within individuals and within families were highly consistent. Heritability estimates for weight, body mass index, fat mass and percentage body fat were approximately 50% for all groups. Heritability for height was lower in Nigeria (62%) than in Jamaica (74%) or the US (87%). CONCLUSION: The familial patterns of body size and energy storage appear to be consistent in these genetically related populations across a wide range of environmental conditions.

Original languageEnglish (US)
Pages (from-to)1034-1041
Number of pages8
JournalInternational Journal of Obesity
Volume25
Issue number7
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Jamaica
heritability
obesity
Nigeria
Obesity
Fats
Population
Adipose Tissue
Body Mass Index
body fat
body mass index
Weights and Measures
lipids
cross cultural studies
Body Size
Leptin
Electric Impedance
Population Groups
bioelectrical impedance
leptin

Keywords

  • Adiposity
  • Black populations
  • Body mass index
  • Leptin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Luke, A., Guo, X., Adeyemo, A. A., Wilks, R., Forrester, T., Lowe, W., ... Cooper, R. S. (2001). Heritability of obesity-related traits among Nigerians, Jamaicans and US black people. International Journal of Obesity, 25(7), 1034-1041. https://doi.org/10.1038/sj.ijo.0801650

Heritability of obesity-related traits among Nigerians, Jamaicans and US black people. / Luke, A.; Guo, X.; Adeyemo, A. A.; Wilks, R.; Forrester, T.; Lowe, W.; Comuzzie, A. G.; Martin, L. J.; Zhu, X.; Rotimi, C. N.; Cooper, R. S.

In: International Journal of Obesity, Vol. 25, No. 7, 2001, p. 1034-1041.

Research output: Contribution to journalArticle

Luke, A, Guo, X, Adeyemo, AA, Wilks, R, Forrester, T, Lowe, W, Comuzzie, AG, Martin, LJ, Zhu, X, Rotimi, CN & Cooper, RS 2001, 'Heritability of obesity-related traits among Nigerians, Jamaicans and US black people', International Journal of Obesity, vol. 25, no. 7, pp. 1034-1041. https://doi.org/10.1038/sj.ijo.0801650
Luke, A. ; Guo, X. ; Adeyemo, A. A. ; Wilks, R. ; Forrester, T. ; Lowe, W. ; Comuzzie, A. G. ; Martin, L. J. ; Zhu, X. ; Rotimi, C. N. ; Cooper, R. S. / Heritability of obesity-related traits among Nigerians, Jamaicans and US black people. In: International Journal of Obesity. 2001 ; Vol. 25, No. 7. pp. 1034-1041.
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abstract = "OBJECTIVE: The mean values for anthropometric traits vary across population groups and this variation is clearly determined for the most part by the environment. The familiarity of anthropometric traits also varies in reports from different populations, although this variation has not been shown to follow a consistent pattern. To examine whether heritability is influenced by socio-cultural factors, we conducted a cross-cultural study of populations of the African diaspora. PARTICIPANTS: Data were collected on 1868 family members from Nigeria, 623 from Jamaica and 2132 from metropolitan Chicago, IL, USA. MEASUREMENTS: Height and weight were measured and body mass index (kg/m2) calculated. Fat-free mass, fat mass and percentage body fat were estimated using bioelectrical impedance analysis. Plasma leptin concentrations were also measured. The proportion of variance attributable to additive genetic and non-shared environmental components was estimated with the maximum likelihood variance decomposition method. RESULTS: Mean values for all anthropometric traits increased along the socio-cultural gradient, and obesity increased from 5{\%} in Nigeria to 23{\%} in Jamaica and 39{\%} in the USA. Within populations the relationships among traits both within individuals and within families were highly consistent. Heritability estimates for weight, body mass index, fat mass and percentage body fat were approximately 50{\%} for all groups. Heritability for height was lower in Nigeria (62{\%}) than in Jamaica (74{\%}) or the US (87{\%}). CONCLUSION: The familial patterns of body size and energy storage appear to be consistent in these genetically related populations across a wide range of environmental conditions.",
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AU - Lowe, W.

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