Heritability of fearful-anxious endophenotypes in infant rhesus macaques: A preliminary report

Douglas E. Williamson, Kris Coleman, Silviu Alin Bacanu, Bernie J. Devlin, Jeffrey Rogers, Neal D. Ryan, Judy L. Cameron

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background: Research efforts to discover the genetic underpinnings of anxiety and depression is challenging because of the etiologic heterogeneity inherent to these disorders. These efforts might be aided by the study of related behavioral phenotypes in model organisms, such as monkeys. Methods: Eighty-five rhesus monkeys (Macaca mulatta) from the Oregon National Primate Research Center were drawn from a standard matriarchal colony and tested for behavioral response in four testing paradigms designed to elicit fearful-anxious reactions. Heritabilities were estimated using variance component-based quantitative genetic analyses with much of the genetic information arising from paternal half-sibs. Results: Individual behaviors reflecting increased distress responses (e.g., vocalizations and teeth grinding) and behavioral inhibition (e.g., latency to leave mother, latency to inspect novel fruit) showed significant heritability, even though a small number of monkeys were assessed. Exploratory factor analyses identified seven clusters of behaviors across tests, some of which were found to be heritable. Conclusions: These results indicate that several specific fearful-anxious behaviors in infant rhesus monkeys are heritable within this colony. Accordingly, these phenotypes, which are believed to represent the genetic liability for anxiety and depression, are good candidates for further genetic investigation in this population.

Original languageEnglish (US)
Pages (from-to)284-291
Number of pages8
JournalBiological Psychiatry
Volume53
Issue number4
DOIs
StatePublished - Feb 15 2003
Externally publishedYes

Fingerprint

Endophenotypes
Macaca mulatta
Haplorhini
Anxiety
Depression
Infant Behavior
Phenotype
Research
Primates
Statistical Factor Analysis
Fruit
Tooth
Mothers
Population

Keywords

  • Anxiety
  • Depression
  • Endophenotypes
  • Heritability
  • Model organisms

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Williamson, D. E., Coleman, K., Bacanu, S. A., Devlin, B. J., Rogers, J., Ryan, N. D., & Cameron, J. L. (2003). Heritability of fearful-anxious endophenotypes in infant rhesus macaques: A preliminary report. Biological Psychiatry, 53(4), 284-291. https://doi.org/10.1016/S0006-3223(02)01601-3

Heritability of fearful-anxious endophenotypes in infant rhesus macaques : A preliminary report. / Williamson, Douglas E.; Coleman, Kris; Bacanu, Silviu Alin; Devlin, Bernie J.; Rogers, Jeffrey; Ryan, Neal D.; Cameron, Judy L.

In: Biological Psychiatry, Vol. 53, No. 4, 15.02.2003, p. 284-291.

Research output: Contribution to journalArticle

Williamson, DE, Coleman, K, Bacanu, SA, Devlin, BJ, Rogers, J, Ryan, ND & Cameron, JL 2003, 'Heritability of fearful-anxious endophenotypes in infant rhesus macaques: A preliminary report', Biological Psychiatry, vol. 53, no. 4, pp. 284-291. https://doi.org/10.1016/S0006-3223(02)01601-3
Williamson, Douglas E. ; Coleman, Kris ; Bacanu, Silviu Alin ; Devlin, Bernie J. ; Rogers, Jeffrey ; Ryan, Neal D. ; Cameron, Judy L. / Heritability of fearful-anxious endophenotypes in infant rhesus macaques : A preliminary report. In: Biological Psychiatry. 2003 ; Vol. 53, No. 4. pp. 284-291.
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