Heritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico City

Arturo Reding-Bernal, Valentin Sánchez-Pedraza, Hortensia Moreno-Macías, Sergio Sobrino-Cossio, María Elizabeth Tejero-Barrera, Ana Isabel Burguete-García, Mireya León-Hernández, María Fabiola Serratos-Canales, Ravindranath Duggirala, Juan Carlos López-Alvarenga

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of this study was to estimate the heritability (h2) and genetic correlation (ρG) between GERD symptoms severity, metabolic syndrome components, and inflammation markers in Mexican families. Methods: Cross-sectional study which included 32 extended families resident in Mexico City. GERD symptoms severity was assessed by the ReQuest in Practice questionnaire. Heritability and genetic correlation were determined using the Sequential Oligogenic Linkage Analysis Routines software. Results: 585 subjects were included, the mean age was 42 (±16.7) years, 57% were women. The heritability of the severity of some GERD symptoms was h2 = 0.27, 0.27, 0.37, and 0.34 (p-value <1.0x10-5) for acidity complaints, lower abdominal complaints, sleep disturbances, and total ReQuest score, respectively. Heritability of metabolic syndrome components ranged from 0.40 for fasting plasma glucose to 0.61 for body mass index and diabetes mellitus. The heritability for fibrinogen and C-reactive protein was 0.64 and 0.38, respectively. Statistically significant genetic correlations were found between acidity complaints and fasting plasma glucose (ρG = 0.40); sleep disturbances and fasting plasma glucose (ρG = 0.36); acidity complaints and diabetes mellitus (ρG = 0.49) and between total ReQuest score and fasting plasma glucose (ρG = 0.43). The rest of metabolic syndrome components did not correlate with GERD symptoms. Conclusion: Genetic factors substantially explain the phenotypic variance of the severity of some GERD symptoms, metabolic syndrome components and inflammation markers. Observed genetic correlations suggest that these phenotypes share common genes. These findings suggest conducting further investigation, as the determination of a linkage analysis in order to identify regions of susceptibility for developing of GERD and metabolic syndrome.

Original languageEnglish (US)
Article numbere0178815
JournalPLoS One
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

family studies
metabolic syndrome
Gastroesophageal Reflux
Mexico
genetic correlation
signs and symptoms (animals and humans)
heritability
inflammation
Acidity
fasting
Inflammation
Plasmas
Glucose
Fasting
acidity
Medical problems
glucose
diabetes mellitus
sleep
linkage (genetics)

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Reding-Bernal, A., Sánchez-Pedraza, V., Moreno-Macías, H., Sobrino-Cossio, S., Tejero-Barrera, M. E., Burguete-García, A. I., ... López-Alvarenga, J. C. (2017). Heritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico City. PLoS One, 12(6), [e0178815]. https://doi.org/10.1371/journal.pone.0178815

Heritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico City. / Reding-Bernal, Arturo; Sánchez-Pedraza, Valentin; Moreno-Macías, Hortensia; Sobrino-Cossio, Sergio; Tejero-Barrera, María Elizabeth; Burguete-García, Ana Isabel; León-Hernández, Mireya; Serratos-Canales, María Fabiola; Duggirala, Ravindranath; López-Alvarenga, Juan Carlos.

In: PLoS One, Vol. 12, No. 6, e0178815, 01.06.2017.

Research output: Contribution to journalArticle

Reding-Bernal, A, Sánchez-Pedraza, V, Moreno-Macías, H, Sobrino-Cossio, S, Tejero-Barrera, ME, Burguete-García, AI, León-Hernández, M, Serratos-Canales, MF, Duggirala, R & López-Alvarenga, JC 2017, 'Heritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico City', PLoS One, vol. 12, no. 6, e0178815. https://doi.org/10.1371/journal.pone.0178815
Reding-Bernal A, Sánchez-Pedraza V, Moreno-Macías H, Sobrino-Cossio S, Tejero-Barrera ME, Burguete-García AI et al. Heritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico City. PLoS One. 2017 Jun 1;12(6). e0178815. https://doi.org/10.1371/journal.pone.0178815
Reding-Bernal, Arturo ; Sánchez-Pedraza, Valentin ; Moreno-Macías, Hortensia ; Sobrino-Cossio, Sergio ; Tejero-Barrera, María Elizabeth ; Burguete-García, Ana Isabel ; León-Hernández, Mireya ; Serratos-Canales, María Fabiola ; Duggirala, Ravindranath ; López-Alvarenga, Juan Carlos. / Heritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico City. In: PLoS One. 2017 ; Vol. 12, No. 6.
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AU - Moreno-Macías, Hortensia

AU - Sobrino-Cossio, Sergio

AU - Tejero-Barrera, María Elizabeth

AU - Burguete-García, Ana Isabel

AU - León-Hernández, Mireya

AU - Serratos-Canales, María Fabiola

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N2 - Objective: The aim of this study was to estimate the heritability (h2) and genetic correlation (ρG) between GERD symptoms severity, metabolic syndrome components, and inflammation markers in Mexican families. Methods: Cross-sectional study which included 32 extended families resident in Mexico City. GERD symptoms severity was assessed by the ReQuest in Practice questionnaire. Heritability and genetic correlation were determined using the Sequential Oligogenic Linkage Analysis Routines software. Results: 585 subjects were included, the mean age was 42 (±16.7) years, 57% were women. The heritability of the severity of some GERD symptoms was h2 = 0.27, 0.27, 0.37, and 0.34 (p-value <1.0x10-5) for acidity complaints, lower abdominal complaints, sleep disturbances, and total ReQuest score, respectively. Heritability of metabolic syndrome components ranged from 0.40 for fasting plasma glucose to 0.61 for body mass index and diabetes mellitus. The heritability for fibrinogen and C-reactive protein was 0.64 and 0.38, respectively. Statistically significant genetic correlations were found between acidity complaints and fasting plasma glucose (ρG = 0.40); sleep disturbances and fasting plasma glucose (ρG = 0.36); acidity complaints and diabetes mellitus (ρG = 0.49) and between total ReQuest score and fasting plasma glucose (ρG = 0.43). The rest of metabolic syndrome components did not correlate with GERD symptoms. Conclusion: Genetic factors substantially explain the phenotypic variance of the severity of some GERD symptoms, metabolic syndrome components and inflammation markers. Observed genetic correlations suggest that these phenotypes share common genes. These findings suggest conducting further investigation, as the determination of a linkage analysis in order to identify regions of susceptibility for developing of GERD and metabolic syndrome.

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