Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study

John F. Keaney, Joseph M. Massaro, Martin G. Larson, Ramachandran S. Vasan, Peter W.F. Wilson, Izabella Lipinska, Diane Corey, Patrice Sutherland, Joseph A. Vita, Emelia J. Benjamin

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Objectives We sought to determine the clinical factors and heritability associated with inflammation measured as circulating levels of soluble-intercellular adhesion molecule-1 (sICAM-1) in a community-based cohort. Background Several prospective studies indicate that circulating sICAM-1 is predictive of future cardiovascular events. However, in some studies this predictive value is lost after multivariable adjustment for traditional cardiovascular disease (CVD) risk factors. We addressed the heritability of sICAM-1 and its relation to CVD risk factors in a community-based cohort. Methods We examined 3,295 subjects from the Framingham Heart Study and measured sICAM-1 levels. We then used linear and stepwise multivariable regression to determine predictors or sICAM-1 levels. Results In age- and gender-adjusted regression models, increased sICAM-1 levels were positively associated with age, total/high-density lipoprotein cholesterol, systolic blood pressure, body mass index (BMI), blood glucose, diabetes, smoking, and prevalent CVD. In stepwise multivariable regression models, sICAM-1 levels remained associated with age, female gender, total/high-density lipoprotein cholesterol ratio, BMI, blood glucose, smoking, and prevalent CVD. The residual heritability of sICAM-1 was 24%. Conclusions In addition to prevalent CVD, established CVD risk factors and non-traditional ones such as BMI were associated with systemic inflammation as determined by sICAM-1 levels. There also is significant heritability of sICAM-1, which suggests a genetic component to systemic inflammation.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalJournal of the American College of Cardiology
Volume44
Issue number1
DOIs
StatePublished - Jul 7 2004
Externally publishedYes

Keywords

  • blood pressure
  • BMI
  • body mass index
  • BP
  • cardiovascular disease
  • CHD
  • CHF
  • congestive heart failure
  • coronary heart disease
  • CVD
  • MI
  • myocardial infarction
  • sICAM-1
  • soluble intracellular adhesion molecule-1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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