@article{85ffa81642684c6fbc7cd621d5844bab,
title = "Heritability and Cognitive Relevance of Structural Brain Controllability",
abstract = "Cognition and behavior are thought to emerge from the connections and interactions among brain regions. The precise nature of these relationships remains elusive. Here we use tools provided by network control theory to determine how the structural connectivity profile of brain regions may shape individual variation in cognition. In a cohort of healthy young adults (n = 1066), we computed two fundamental brain regional control patterns, average and modal controllability, which index the degree of influence of a region over others. We first established that regional brain controllability measures were both reproducible and heritable. Regions with controllability profiles theoretically conducive to facilitating multiple cognitive operations were over-represented in higher-order resting-state networks. Finally, variation in regional controllability accounted for about 50% of interindividual variability in multiple cognitive domains. We conclude that controllability is a biologically plausible property of the structural connectome and provides a mechanistic explanation for how brain structural architecture may influence cognitive functions.",
keywords = "cognition, controllability, diffusion magnetic resonance imaging, structural connectivity",
author = "Lee, {Won Hee} and Amanda Rodrigue and Glahn, {David C.} and Bassett, {Danielle S.} and Sophia Frangou",
note = "Funding Information: National Institute of Mental Health (grant R01MH113619); the John D. and Catherine T. MacArthur Foundation; the Alfred P. Sloan Foundation; the ISI Foundation; the Paul Allen Foundation; the Army Research Laboratory (W911NF-10-2-0022); the Army Research Office (Bassett-W911NF-14-1-0679, Grafton-W911NF-16-1-0474, DCIST-W911NF-17-2-0181); the Office of Naval Research; the National Institute of Mental Health (2-R01-DC-009209-11, R01-MH112847, R01-MH107235, R21-M MH-106799, R01-M MH-113550); the National Institute of Neurological Disorders and Stroke (R01 NS099348); the National Institute of Child Health and Human Development (1R01HD086888-01); the National Science Foundation (BCS-1441502, BCS-1430087, NSF PHY-1554488, BCS-1631550) to D.S.B. Data were provided by the Human Connectome Project (HCP), and the Washington University, University of Minnesota, and Oxford University Consortium (Principal Investigators David Van Essen and Kamil Ugurbil; Grant 1U54MH091657) funded by 16 National Institutes of Health and Centers that support the NIH Blueprint for Neuroscience Research, and the McDonnell Center for Systems Neuroscience at Washington University. Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press. All rights reserved.",
year = "2020",
month = may,
day = "14",
doi = "10.1093/cercor/bhz293",
language = "English (US)",
volume = "30",
pages = "3044--3054",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "5",
}