Hereditary and dietary effects on apolipoprotein[a] isoforms and Lp[a] in baboons

D. L. Rainwater, G. S. Manis, J. L. VandeBerg

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    55 Scopus citations

    Abstract

    Baboons possess Lp[a] that is similar to human Lp[a], including the presence of the unique protein, apo[a]. Baboon apo[a] occurred in at least nine isoforms distinguishable by size. Isoforms were resolved by 3-12% polyacrylamide gradient gel electrophoretic separation of serum proteins, and were detected with baboon apo[a]-specific antibodies. Thirty one different apo[a] isoform phenotypes were detected in a population of 165 unrelated baboons. Identical isoform phenotypes were observed in different samples from individual baboons, and isoform phenotypes were unaffected by changes in diet. In one experiment, 16 baboons were fed a series of five diets differing in amounts of cholesterol and saturated or unsaturated fats. There was no significant effect of diet on serum Lp[a] levels. In another group of baboons (n = 70) controlled for age and dietary history, enrichment of the diet with cholesterol and saturated fat caused a small, but significant (P < 0.005), increase (X̄ = 0.6 mg/dl) in serum Lp[a] concentration. Analysis of two large sire families suggested that apo[a] isoform patterns and serum Lp[a] concentrations were inherited. Putative parental alleles responsible for specific isoform bands appeared to segregate randomly. Heritability (h2) of serum Lp[a] concentration was estimated to be 0.95 ± 0.04. We conclude that apo[a] isoform phenotypes and serum Lp[a] concentrations are inherited, and that Lp[a] concentrations are only slightly influenced by diet.

    Original languageEnglish (US)
    Pages (from-to)549-558
    Number of pages10
    JournalJournal of lipid research
    Volume30
    Issue number4
    StatePublished - Jan 1 1989

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Cell Biology

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    Rainwater, D. L., Manis, G. S., & VandeBerg, J. L. (1989). Hereditary and dietary effects on apolipoprotein[a] isoforms and Lp[a] in baboons. Journal of lipid research, 30(4), 549-558.