Hereditary and dietary effects on apolipoprotein[a] isoforms and Lp[a] in baboons

D. L. Rainwater, G. S. Manis, J. L. VandeBerg

Research output: Contribution to journalArticle

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Abstract

Baboons possess Lp[a] that is similar to human Lp[a], including the presence of the unique protein, apo[a]. Baboon apo[a] occurred in at least nine isoforms distinguishable by size. Isoforms were resolved by 3-12% polyacrylamide gradient gel electrophoretic separation of serum proteins, and were detected with baboon apo[a]-specific antibodies. Thirty one different apo[a] isoform phenotypes were detected in a population of 165 unrelated baboons. Identical isoform phenotypes were observed in different samples from individual baboons, and isoform phenotypes were unaffected by changes in diet. In one experiment, 16 baboons were fed a series of five diets differing in amounts of cholesterol and saturated or unsaturated fats. There was no significant effect of diet on serum Lp[a] levels. In another group of baboons (n = 70) controlled for age and dietary history, enrichment of the diet with cholesterol and saturated fat caused a small, but significant (P < 0.005), increase (X̄ = 0.6 mg/dl) in serum Lp[a] concentration. Analysis of two large sire families suggested that apo[a] isoform patterns and serum Lp[a] concentrations were inherited. Putative parental alleles responsible for specific isoform bands appeared to segregate randomly. Heritability (h2) of serum Lp[a] concentration was estimated to be 0.95 ± 0.04. We conclude that apo[a] isoform phenotypes and serum Lp[a] concentrations are inherited, and that Lp[a] concentrations are only slightly influenced by diet.

Original languageEnglish (US)
Pages (from-to)549-558
Number of pages10
JournalJournal of Lipid Research
Volume30
Issue number4
StatePublished - 1989
Externally publishedYes

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Apoprotein(a)
Papio
Apolipoproteins
Protein Isoforms
Nutrition
Diet
Phenotype
Serum
Cholesterol
Unsaturated Fats
Blood Proteins
Gels
Fats
Alleles
Antibodies

ASJC Scopus subject areas

  • Endocrinology

Cite this

Rainwater, D. L., Manis, G. S., & VandeBerg, J. L. (1989). Hereditary and dietary effects on apolipoprotein[a] isoforms and Lp[a] in baboons. Journal of Lipid Research, 30(4), 549-558.

Hereditary and dietary effects on apolipoprotein[a] isoforms and Lp[a] in baboons. / Rainwater, D. L.; Manis, G. S.; VandeBerg, J. L.

In: Journal of Lipid Research, Vol. 30, No. 4, 1989, p. 549-558.

Research output: Contribution to journalArticle

Rainwater, DL, Manis, GS & VandeBerg, JL 1989, 'Hereditary and dietary effects on apolipoprotein[a] isoforms and Lp[a] in baboons', Journal of Lipid Research, vol. 30, no. 4, pp. 549-558.
Rainwater, D. L. ; Manis, G. S. ; VandeBerg, J. L. / Hereditary and dietary effects on apolipoprotein[a] isoforms and Lp[a] in baboons. In: Journal of Lipid Research. 1989 ; Vol. 30, No. 4. pp. 549-558.
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