Hepatotoxicidade grave secundária a psicofármacos e indicação de eletroconvulsoterapia a paciente com esquizofrenia

Maila De Castro Neves; Arthur Kummer; Luciana Monteiro Luciano; Hélio Lauar; João Vinícius Salgado; Rodrigo Nicolato; Antônio Lúcio Teixeira

doi:10.1590/s0047-20852006000100011

Hepatotoxicidade grave secundária a psicofármacos e indicação de eletroconvulsoterapia a paciente com esquizofrenia

Translated title of the contribution: Severe psychotropic-induced hepatotoxicity and indication of electroconvulsive therapy in a patient with schizophrenia

Maila De Castro Neves
, Arthur Kummer
, Luciana Monteiro Luciano
, Hélio Lauar
, João Vinícius Salgado
, Rodrigo Nicolato
, Antônio Lúcio Teixeira

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report the case of a patient with paranoid schizophrenia who developed two episodes of severe hepatotoxicity. They were attributed to the side effects of valproic acid and clozapine. This relationship was established by the temporal proximity between the onset of medication and the development of side effects, the clinical remission after drug cessation and the exclusion of other causes of hepatic diseases. On the follow-up, the patient was treated with eletroconvulsive therapy. This case report highlights the relevance of careful vigilance of adverse effects of psychotropics, especially hepatotoxicity, and the role of eletroconvulsive therapy when there are pharmacological constraints.

Translated title of the contribution	Severe psychotropic-induced hepatotoxicity and indication of electroconvulsive therapy in a patient with schizophrenia
Original language	Portuguese
Pages (from-to)	74-77
Number of pages	4
Journal	Jornal Brasileiro de Psiquiatria
Volume	55
Issue number	1
DOIs	https://doi.org/10.1590/s0047-20852006000100011
State	Published - 2006
Externally published	Yes

Keywords

Clozapine
Eletroconvulsive therapy
Hepatotoxicity
Valproic acid

ASJC Scopus subject areas

Psychiatry and Mental health

Access to Document

10.1590/s0047-20852006000100011

Cite this

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title = "Hepatotoxicidade grave secund{\'a}ria a psicof{\'a}rmacos e indica{\c c}{\~a}o de eletroconvulsoterapia a paciente com esquizofrenia",

abstract = "We report the case of a patient with paranoid schizophrenia who developed two episodes of severe hepatotoxicity. They were attributed to the side effects of valproic acid and clozapine. This relationship was established by the temporal proximity between the onset of medication and the development of side effects, the clinical remission after drug cessation and the exclusion of other causes of hepatic diseases. On the follow-up, the patient was treated with eletroconvulsive therapy. This case report highlights the relevance of careful vigilance of adverse effects of psychotropics, especially hepatotoxicity, and the role of eletroconvulsive therapy when there are pharmacological constraints.",

keywords = "Clozapine, Eletroconvulsive therapy, Hepatotoxicity, Valproic acid",

author = "\{De Castro Neves\}, Maila and Arthur Kummer and \{Monteiro Luciano\}, Luciana and H{\'e}lio Lauar and \{Vin{\'i}cius Salgado\}, Jo{\~a}o and Rodrigo Nicolato and Teixeira, \{Ant{\^o}nio L{\'u}cio\}",

year = "2006",

doi = "10.1590/s0047-20852006000100011",

language = "Portuguese",

volume = "55",

pages = "74--77",

journal = "Jornal Brasileiro de Psiquiatria",

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number = "1",

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T1 - Hepatotoxicidade grave secundária a psicofármacos e indicação de eletroconvulsoterapia a paciente com esquizofrenia

AU - De Castro Neves, Maila

AU - Kummer, Arthur

AU - Monteiro Luciano, Luciana

AU - Lauar, Hélio

AU - Vinícius Salgado, João

AU - Nicolato, Rodrigo

AU - Teixeira, Antônio Lúcio

PY - 2006

Y1 - 2006

N2 - We report the case of a patient with paranoid schizophrenia who developed two episodes of severe hepatotoxicity. They were attributed to the side effects of valproic acid and clozapine. This relationship was established by the temporal proximity between the onset of medication and the development of side effects, the clinical remission after drug cessation and the exclusion of other causes of hepatic diseases. On the follow-up, the patient was treated with eletroconvulsive therapy. This case report highlights the relevance of careful vigilance of adverse effects of psychotropics, especially hepatotoxicity, and the role of eletroconvulsive therapy when there are pharmacological constraints.

AB - We report the case of a patient with paranoid schizophrenia who developed two episodes of severe hepatotoxicity. They were attributed to the side effects of valproic acid and clozapine. This relationship was established by the temporal proximity between the onset of medication and the development of side effects, the clinical remission after drug cessation and the exclusion of other causes of hepatic diseases. On the follow-up, the patient was treated with eletroconvulsive therapy. This case report highlights the relevance of careful vigilance of adverse effects of psychotropics, especially hepatotoxicity, and the role of eletroconvulsive therapy when there are pharmacological constraints.

KW - Clozapine

KW - Eletroconvulsive therapy

KW - Hepatotoxicity

KW - Valproic acid

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U2 - 10.1590/s0047-20852006000100011

DO - 10.1590/s0047-20852006000100011

M3 - Article

AN - SCOPUS:33744906279

SN - 0047-2085

VL - 55

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JO - Jornal Brasileiro de Psiquiatria

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Hepatotoxicidade grave secundária a psicofármacos e indicação de eletroconvulsoterapia a paciente com esquizofrenia

Abstract

Keywords

ASJC Scopus subject areas

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