Hepatocellular carcinoma: An update

Tram T. Tran, F. Fred Poordad, Nicholas Nissen, Paul Martin

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Hepatocellular carcinoma (HCC) is the fifth most common malignancy in men and the eighth in women worldwide, accounting for nearly 1 million deaths annually. Its incidence has increased nearly 75% during the past decade in the United States, and HCC is now recognized as an all too frequent complication of chronic liver disease. Chronic infection with the hepatitis B (HBV) or hepatitis C virus (HCV) is most frequently implicated in HCC, although other etiologies of cirrhosis, including alcohol and hemochromatosis, also have an increased risk. The prognosis for HCC is poor, with a 5-year survival of only 6% after diagnosis. Screening and early detection are important, because surgical resection or liver transplantation offer the only chances for long-term survival. For patients in whom surgical treatment is not an option because of advanced disease or comorbidities, newer modalities are being studied.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalClinical Perspectives in Gastroenterology
Issue number5
StatePublished - Sep 2002
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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