Hepatobiliary transport in health and disease

Jeannie Chan, John L. Vandeberg

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Bile salts, cholesterol and phosphatidylcholine are secreted across the canalicular membrane of hepatocytes into bile by ATP-binding cassette (ABC) transporters. Secretion of bile salts by ABCB11 is essential for bile flow and for absorption of lipids and fat-soluble vitamins. ABCG5 and ABCG8 eliminate excess cholesterol and sterols from the body by secreting them into bile. There are two mechanisms to protect the canalicular membrane from solubilization by bile salts; ABCB4 secretes phosphatidylcholine into bile to form mixed micelles with bile salts, and ATP8B1 maintains the canalicular membrane in a liquid-ordered state. Three different forms of progressive familial intrahepatic cholestasis (PFIC) disorders, PFIC1, PFIC2 and PFIC3, are caused by mutations in ATP8B1, ABCB11 and ABCB4, respectively. Sitosterolemia is caused by mutations in ABCG5 and ABCG8. This article reviews the physiological roles of these canalicular transporters, and the pathophysiological processes and clinical features associated with their mutations.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalClinical Lipidology
Volume7
Issue number2
DOIs
StatePublished - Apr 2012
Externally publishedYes

Keywords

  • ATP-binding cassette transporter
  • P4 ATPase
  • bile
  • canalicular membrane
  • cholestasis
  • cholesterol
  • phospholipids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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