Hepatitis C virus infection in chronic haemodialysis patients, a clinicopathologic study

O. Alfurayh, M. Sobh, A. R. Buali, M. Ashraf Ali, Y. Barri, Wajeh Y Qunibi, S. Taher

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Fifty-two patients on regular haemodialysis at our institution were evaluated for the presence of HCV infection. Evaluation included detailed history, clinical examination, and monthly screeninlg for anti-HCV antibody, liver enzymes (ALT, AST), serum iron and ferritin. Also, three-monthly screening for other viral markers, HBV (HBsAg, HBsAb, HBcAb), (CMV (IgG and IgM), EBV, and HIV. Anti-HCV antibody was found in 21 patients (40.4%). There was a significant (P < 0.05) relationship between presence of anti-HCV antibody and proportion of patients who received blood transfusion. During a 12-month follow-up, four (11.4%) patients seroconverted to be Anti-HCV positive while one case (4.8%) seroconverted to be anti-HCV negative. The frequency of elevation of liver enzymes was significantly higher in Anti-HCV positive cases (14/18) than in negative cases (11/28, P = 0.01). Evaluation of liver biopsies of 13 patients showed chronic persistent hepatitis in six and chronic active hepatitis in seven cases. We concluded that hepatitis C is a common problem among chronic haemodialysis patients at our institution; HCV infection is documented in 70% of all clinically diagnosed NANB hepatitis. Presence of anti-HCV antibodies cannot differentiate between active and past infection and cases with early HCV infection can be missed when relying on the mere detection of anti-HCV antibodies.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalNephrology Dialysis Transplantation
Volume7
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Virus Diseases
Hepatitis C Antibodies
Hepacivirus
Renal Dialysis
Chronic Hepatitis
Infection
Liver
Enzymes
Ferritins
Hepatitis C
Hepatitis B Surface Antigens
Human Herpesvirus 4
Blood Transfusion
Hepatitis
Immunoglobulin M
Iron
Immunoglobulin G
Biomarkers
History
HIV

Keywords

  • Dialysis
  • Hepatitis C virus

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Alfurayh, O., Sobh, M., Buali, A. R., Ashraf Ali, M., Barri, Y., Qunibi, W. Y., & Taher, S. (1992). Hepatitis C virus infection in chronic haemodialysis patients, a clinicopathologic study. Nephrology Dialysis Transplantation, 7(4), 327-332.

Hepatitis C virus infection in chronic haemodialysis patients, a clinicopathologic study. / Alfurayh, O.; Sobh, M.; Buali, A. R.; Ashraf Ali, M.; Barri, Y.; Qunibi, Wajeh Y; Taher, S.

In: Nephrology Dialysis Transplantation, Vol. 7, No. 4, 1992, p. 327-332.

Research output: Contribution to journalArticle

Alfurayh, O, Sobh, M, Buali, AR, Ashraf Ali, M, Barri, Y, Qunibi, WY & Taher, S 1992, 'Hepatitis C virus infection in chronic haemodialysis patients, a clinicopathologic study', Nephrology Dialysis Transplantation, vol. 7, no. 4, pp. 327-332.
Alfurayh O, Sobh M, Buali AR, Ashraf Ali M, Barri Y, Qunibi WY et al. Hepatitis C virus infection in chronic haemodialysis patients, a clinicopathologic study. Nephrology Dialysis Transplantation. 1992;7(4):327-332.
Alfurayh, O. ; Sobh, M. ; Buali, A. R. ; Ashraf Ali, M. ; Barri, Y. ; Qunibi, Wajeh Y ; Taher, S. / Hepatitis C virus infection in chronic haemodialysis patients, a clinicopathologic study. In: Nephrology Dialysis Transplantation. 1992 ; Vol. 7, No. 4. pp. 327-332.
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