Hepatitis C therapeutics: Current status and emerging strategies

Seng Lai Tan, Arnim Pause, Yuguang Shi, Nahum Sonenberg

Research output: Contribution to journalReview articlepeer-review

210 Scopus citations


Chronic infection with hepatitis C virus (HCV) is an emerging global epidemic. The development of effective HCV antiviral therapeutics continues to be a daunting challenge owing to the absence of adequate animal models and tissue-culture systems for analysis and propagation of the virus. Despite these obstacles, inhibitors of the replicative elements of HCV, immune modulators and non-specific hepatoprotective agents are being pursued and exciting progress has been made. Successful therapeutic intervention of HCV will probably require combination approaches and new approaches, including host drug discovery targets.

Original languageEnglish (US)
Pages (from-to)867-881
Number of pages15
JournalNature Reviews Drug Discovery
Issue number11
StatePublished - Nov 2002
Externally publishedYes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology


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