Hepatic failure secondary to indicine n‐oxide toxicity. A pediatric oncology group study

Bruce A. Cook; John R. Sinnhuber; Paul J. Thomas; Thomas A. Olson; Toby A. Silverman; Robert Jones; V. Michael Whitehead; Frederick B. Ruymann

doi:10.1002/1097-0142(19830701)52:1<61::AID-CNCR2820520112>3.0.CO;2-W

Hepatic failure secondary to indicine n‐oxide toxicity. A pediatric oncology group study

Bruce A. Cook, John R. Sinnhuber, Paul J. Thomas, Thomas A. Olson, Toby A. Silverman, Robert Jones, V. Michael Whitehead, Frederick B. Ruymann

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Indicine N‐oxide, a pyrrolizidine alkaloid, was given to a five‐year‐old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N‐oxide toxicity. Cancer 52:61‐63, 1983.

Original language	English (US)
Pages (from-to)	61-63
Number of pages	3
Journal	Cancer
Volume	52
Issue number	1
DOIs	https://doi.org/10.1002/1097-0142(19830701)52:1<61::AID-CNCR2820520112>3.0.CO;2-W
State	Published - Jul 1 1983
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19830701)52:1<61::AID-CNCR2820520112>3.0.CO;2-W

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abstract = "Indicine N‐oxide, a pyrrolizidine alkaloid, was given to a five‐year‐old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N‐oxide toxicity. Cancer 52:61‐63, 1983.",

author = "Cook, {Bruce A.} and Sinnhuber, {John R.} and Thomas, {Paul J.} and Olson, {Thomas A.} and Silverman, {Toby A.} and Robert Jones and Whitehead, {V. Michael} and Ruymann, {Frederick B.}",

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T1 - Hepatic failure secondary to indicine n‐oxide toxicity. A pediatric oncology group study

AU - Cook, Bruce A.

AU - Sinnhuber, John R.

AU - Thomas, Paul J.

AU - Olson, Thomas A.

AU - Silverman, Toby A.

AU - Jones, Robert

AU - Whitehead, V. Michael

AU - Ruymann, Frederick B.

PY - 1983/7/1

Y1 - 1983/7/1

N2 - Indicine N‐oxide, a pyrrolizidine alkaloid, was given to a five‐year‐old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N‐oxide toxicity. Cancer 52:61‐63, 1983.

AB - Indicine N‐oxide, a pyrrolizidine alkaloid, was given to a five‐year‐old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N‐oxide toxicity. Cancer 52:61‐63, 1983.

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Hepatic failure secondary to indicine n‐oxide toxicity. A pediatric oncology group study

Abstract

ASJC Scopus subject areas

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