Hepatic and Wernicke's encephalopathies: Current concepts of pathogenesis

S. Schenker, G. I. Henderson, A. M. Hoyumpa, D. W. McCandless

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


The aim of this brief review is to assess the current state of knowledge of the pathogenesis of hepatic and Wernicke's encephalopathy. The common theme of these two disorders is that they both occur most frequently in the setting of alcoholism and that they are potentially fully and rapidly reversible with appropriate treatment implying a metabolic (i.e., neurochemical/neurophysiological) encephalopathy, as contrasted to one characterized by fixed structural lesions (i.e., cerebrovascular insult).

Original languageEnglish (US)
Pages (from-to)2719-2726
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Issue number12
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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