Hemorrhagic gastritis in cirrhotics: A prostaglandin connection?

B. A. Levine, Wayne H Schwesinger, Kenneth R Sirinek

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cirrhotics with portal hypertension have a high incidence of upper gastrointestinal hemorrhage secondary to diffuse gastritis. Previous studies have identified intrinsic abnormalities in portal hypertensive gastric mucosa, including a decreased ability to generate cytoprotective prostaglandins. This study investigated the effect of operative portal decompression on gastric mucosal prostaglandin generation (PGI2 and PGE2) in patients with alcoholic cirrhosis. Findings included: (1) decreased mucosal prostaglandins in unoperated portal hypertensives compared to normal controls and (2) return of mucosal prostaglandin generation to normal following portacaval shunting. In addition, follow-up in 210 survivors of portasystemic shunting demonstrated only six instances of UGI hemorrhage from diffuse gastritis. These results suggest: (1) an association of portal venous pressure with gastric mucosal prostaglandin generation and (2) a possible etiologic role for disturbed prostaglandin synthesis in portal hypertensive hemorrhagic gastritis.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalSurgical Research Communications
Volume10
Issue number1
StatePublished - 1991

Fingerprint

Gastritis
Prostaglandins
Stomach
Portal Pressure
Alcoholic Liver Cirrhosis
Gastrointestinal Hemorrhage
Portal Hypertension
Epoprostenol
Gastric Mucosa
Decompression
Dinoprostone
Survivors
Hemorrhage
Incidence

Keywords

  • gastric mucosa
  • portal hypertension
  • Prostaglandin

ASJC Scopus subject areas

  • Surgery

Cite this

Hemorrhagic gastritis in cirrhotics : A prostaglandin connection? / Levine, B. A.; Schwesinger, Wayne H; Sirinek, Kenneth R.

In: Surgical Research Communications, Vol. 10, No. 1, 1991, p. 15-20.

Research output: Contribution to journalArticle

Levine, B. A. ; Schwesinger, Wayne H ; Sirinek, Kenneth R. / Hemorrhagic gastritis in cirrhotics : A prostaglandin connection?. In: Surgical Research Communications. 1991 ; Vol. 10, No. 1. pp. 15-20.
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