Hemorrhagic gastritis in cirrhotics: A prostaglandin connection?

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Abstract

Cirrhotics with portal hypertension have a high incidence of upper gastrointestinal hemorrhage secondary to diffuse gastritis. Previous studies have identified intrinsic abnormalities in portal hypertensive gastric mucosa, including a decreased ability to generate cytoprotective prostaglandins. This study investigated the effect of operative portal decompression on gastric mucosal prostaglandin generation (PGI2 and PGE2) in patients with alcoholic cirrhosis. Findings included: (1) decreased mucosal prostaglandins in unoperated portal hypertensives compared to normal controls and (2) return of mucosal prostaglandin generation to normal following portacaval shunting. In addition, follow-up in 210 survivors of portasystemic shunting demonstrated only six instances of UGI hemorrhage from diffuse gastritis. These results suggest: (1) an association of portal venous pressure with gastric mucosal prostaglandin generation and (2) a possible etiologic role for disturbed prostaglandin synthesis in portal hypertensive hemorrhagic gastritis.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalSurgical Research Communications
Volume10
Issue number1
StatePublished - Jan 1 1991

Keywords

  • Prostaglandin
  • gastric mucosa
  • portal hypertension

ASJC Scopus subject areas

  • Surgery

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