Hemophilia growth and development study: Relationships between neuropsychological, neurological, and MRI findings at baseline

Patricia A. Sirois, Dale W. Usner, Suzanne D. Hill, Wendy G. Mitchell, James F. Bale, Katherine A. Loveland, James A. Stehbens, Sharyne M. Donfield, Margaret A. Maeder, Nancy Amodei, Charles F. Contant, Marvin D. Nelson, John K. Willis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objective: To determine the effects of human immunodeficiency virus (HIV) infection on children's development by identifying neurological and environmental variables associated with neuropsychological measures of cognitive development in HIV-seronegative (HIV-) and HIV-seropositive (HIV+) children and adolescents with hemophilia. Methods: Participants (N = 298; 60% HIV+) were males ages 7-19 years enrolled in the Hemophilia Growth and Development Study (HGDS). Least squares modeling was used to determine whether there was a difference at baseline in mean neuropsychological test scores by HIV status, age, and neurological baseline findings, adjusting for selected environmental and medical history variables. Results: The participants were within age expectations for general intelligence. Variables associated with lowered neuropsychological performance included academic problems, coordination and/or gait abnormallties, parents' education, and previous head trauma. Conclusions: Hemophilia-related morbidity has a subtle adverse influence on cognitive performance. HIV infection was not associated with neuropsychological dysfunction in this group even when MRI abnormalities were present.

Original languageEnglish (US)
Pages (from-to)45-56
Number of pages12
JournalJournal of Pediatric Psychology
Volume23
Issue number1
DOIs
StatePublished - Feb 1998

Keywords

  • Child development
  • Hemophilia
  • Human immunodeficiency virus (HIV)
  • MRI
  • Neurology
  • Neuropsychology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology

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