TY - JOUR
T1 - Hemoglobin Fannin-Lubbock [α2β2119(GH2) Gly → Asp]. A New Hemoglobin Variant at the α1β1 Contact
AU - Moo-Penn, Winston F.
AU - C.Bechtel, Katherine
AU - Johnson, Mary H.
AU - Jue, Danny L.
AU - Bradford, L.
AU - Therrell, Jr
AU - Morrison, Barbara Y.
AU - Schmidt, Robert M.
PY - 1976/12/22
Y1 - 1976/12/22
N2 - Hemoglobin Fannin-Lubbock was found in a 9-year-old Mexican-American female. The abnormal hemoglobin was detected as a fast-moving variant by electrophoresis on cellulose acetate at pH 8.4. Structural analysis indicated a substitution in the β-chain of aspartic acid for glycine at position 119, a position involved in the α1β1 contact of the hemoglobin tetramer. This contact between unlike chains is larger and undergoes a smaller shift during the process of oxygenation and deoxygenation than the α1β2 contact (Perutz, M.F., Muirhead, H., Cox, J.M. and Goaman L.C.G. (1968) Nature 219, 131-139). Mutations in this contact tend to cause slight or no changes in functional behavior. Apart from a mild anemia, the propositus did not exhibit any obvious clinical symptoms.
AB - Hemoglobin Fannin-Lubbock was found in a 9-year-old Mexican-American female. The abnormal hemoglobin was detected as a fast-moving variant by electrophoresis on cellulose acetate at pH 8.4. Structural analysis indicated a substitution in the β-chain of aspartic acid for glycine at position 119, a position involved in the α1β1 contact of the hemoglobin tetramer. This contact between unlike chains is larger and undergoes a smaller shift during the process of oxygenation and deoxygenation than the α1β2 contact (Perutz, M.F., Muirhead, H., Cox, J.M. and Goaman L.C.G. (1968) Nature 219, 131-139). Mutations in this contact tend to cause slight or no changes in functional behavior. Apart from a mild anemia, the propositus did not exhibit any obvious clinical symptoms.
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U2 - 10.1016/0005-2795(76)90142-2
DO - 10.1016/0005-2795(76)90142-2
M3 - Article
C2 - 11828
AN - SCOPUS:0017194665
VL - 453
SP - 472
EP - 477
JO - BBA - Protein Structure
JF - BBA - Protein Structure
SN - 1570-9639
IS - 2
ER -