Hemodynamic effects of intravenous prostacyclin in stable angina pectoris

Brian G. Firth, Michael D. Winniford, William B. Campbell, L. David Hillis

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Prostacyclin (PGI2) is a naturally occurring vasodilator and inhibitor of platelet aggregation that produces vasodilatation of the systemic, pulmonary and coronary vascular beds in animal models. Because the endogenous production of PGI2 is reduced in those with coronary arterial disease (CAD), it may have a therapeutic role in patients with ischemic heart disease. To assess its safety and efficacy in this clinical setting, 17 patients with stable angina and CAD received an incremental intravenous infusion of either PGI2 (n = 10) to a maximum dose of 10 ng/kg/min (average 9.8 ± 0.8 [mean ± standard deviation]), or diluent buffer solution (placebo) (n = 7). All patients who received PGI2 became flushed, but experienced no other adverse effects. PGI2 caused an increase in heart rate (66 ± 11 to 80 ± 11 beats/min, p <0.001) and cardiac index (2.88 ± 0.65 to 3.97 ± 1.17 liters/min/m2, p <0.001) and a decrease in mean femoral arterial pressure (96 ± 18 to 86 ± 11 mm Hg, p <0.001), but no change in mean pulmonary arterial or capillary wedge pressure. Total systemic and pulmonary vascular resistance decreased significantly (p <0.001). In response to PGI2, mean coronary sinus blood flow did not change significantly (100 ± 40 to 121 ± 52 ml/min), but coronary vascular resistance decreased (1.07 ± 0.40 to 0.83 ± 0.36 U, p <0.001). No variable was altered by placebo infusion. PGI2 caused a marked increase in 6-keto PGF (the stable metabolite of PGI2) concentrations in both arterial (42 ± 29 to 567 ± 216 pg/ml, p <0.001) and venous (46 ± 31 to 604 ± 229 pg/ml, p <0.001) blood but no demonstrable change in plasma renin activity. Thus, intravenous PGI2 to a dosage of 10 ng/kg/min is a safe and effective systemic, pulmonary and coronary arterial vasodilator in patients with CAD and stable angina pectoris.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalThe American journal of cardiology
Volume52
Issue number5
DOIs
StatePublished - Sep 1 1983

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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