Abstract
The injection of a sublethal bolus of E. coli into conscious swine produces an early increase in pulmonary arterial pressure (PAP) and a decrease in left atrial pressure (LAP). This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to demonstrated multiple pulmonary microemboli. Hypoxemia developed in only 4 of 17 animals although all endotoxin treated swine showed interstitial edema and elevated wet/dry weight ratios with normal pulmonary surfactant. In addition, endotoxin treated swine developed signs of disseminated intravascular coagulation, with renal cortical infarcts in 44%, and coronary arterial thrombi in 28% including one transmural myocardial infarction. This effect was observed in the absence of prolonged hypotension in swine and should provide a useful model for further study of the relationship of endotoxin to disseminated intravascular coagulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 184-190 |
| Number of pages | 7 |
| Journal | Journal of Trauma |
| Volume | 16 |
| Issue number | 3 |
| State | Published - 1976 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
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Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin. / Brown, P. P.; Coalson, J. J.; Elkins, R. C.; Hinshaw, L. B.; Greenfield, L. J.
In: Journal of Trauma, Vol. 16, No. 3, 1976, p. 184-190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin
AU - Brown, P. P.
AU - Coalson, J. J.
AU - Elkins, R. C.
AU - Hinshaw, L. B.
AU - Greenfield, L. J.
PY - 1976
Y1 - 1976
N2 - The injection of a sublethal bolus of E. coli into conscious swine produces an early increase in pulmonary arterial pressure (PAP) and a decrease in left atrial pressure (LAP). This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to demonstrated multiple pulmonary microemboli. Hypoxemia developed in only 4 of 17 animals although all endotoxin treated swine showed interstitial edema and elevated wet/dry weight ratios with normal pulmonary surfactant. In addition, endotoxin treated swine developed signs of disseminated intravascular coagulation, with renal cortical infarcts in 44%, and coronary arterial thrombi in 28% including one transmural myocardial infarction. This effect was observed in the absence of prolonged hypotension in swine and should provide a useful model for further study of the relationship of endotoxin to disseminated intravascular coagulation.
AB - The injection of a sublethal bolus of E. coli into conscious swine produces an early increase in pulmonary arterial pressure (PAP) and a decrease in left atrial pressure (LAP). This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to demonstrated multiple pulmonary microemboli. Hypoxemia developed in only 4 of 17 animals although all endotoxin treated swine showed interstitial edema and elevated wet/dry weight ratios with normal pulmonary surfactant. In addition, endotoxin treated swine developed signs of disseminated intravascular coagulation, with renal cortical infarcts in 44%, and coronary arterial thrombi in 28% including one transmural myocardial infarction. This effect was observed in the absence of prolonged hypotension in swine and should provide a useful model for further study of the relationship of endotoxin to disseminated intravascular coagulation.
UR - http://www.scopus.com/inward/record.url?scp=0017259170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017259170&partnerID=8YFLogxK
M3 - Article
C2 - 3664
AN - SCOPUS:0017259170
VL - 16
SP - 184
EP - 190
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
SN - 2163-0755
IS - 3
ER -