Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin

P. P. Brown, J. J. Coalson, R. C. Elkins, L. B. Hinshaw, L. J. Greenfield

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The injection of a sublethal bolus of E. coli into conscious swine produces an early increase in pulmonary arterial pressure (PAP) and a decrease in left atrial pressure (LAP). This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to demonstrated multiple pulmonary microemboli. Hypoxemia developed in only 4 of 17 animals although all endotoxin treated swine showed interstitial edema and elevated wet/dry weight ratios with normal pulmonary surfactant. In addition, endotoxin treated swine developed signs of disseminated intravascular coagulation, with renal cortical infarcts in 44%, and coronary arterial thrombi in 28% including one transmural myocardial infarction. This effect was observed in the absence of prolonged hypotension in swine and should provide a useful model for further study of the relationship of endotoxin to disseminated intravascular coagulation.

Original languageEnglish (US)
Pages (from-to)184-190
Number of pages7
JournalJournal of Trauma
Volume16
Issue number3
StatePublished - 1976
Externally publishedYes

Fingerprint

Endotoxins
Swine
Hemodynamics
Escherichia coli
Disseminated Intravascular Coagulation
Lung
Pulmonary Surfactants
Atrial Pressure
Constriction
Hypotension
Edema
Arterial Pressure
Thrombosis
Myocardial Infarction
Kidney
Weights and Measures
Injections

ASJC Scopus subject areas

  • Surgery

Cite this

Brown, P. P., Coalson, J. J., Elkins, R. C., Hinshaw, L. B., & Greenfield, L. J. (1976). Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin. Journal of Trauma, 16(3), 184-190.

Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin. / Brown, P. P.; Coalson, J. J.; Elkins, R. C.; Hinshaw, L. B.; Greenfield, L. J.

In: Journal of Trauma, Vol. 16, No. 3, 1976, p. 184-190.

Research output: Contribution to journalArticle

Brown, PP, Coalson, JJ, Elkins, RC, Hinshaw, LB & Greenfield, LJ 1976, 'Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin', Journal of Trauma, vol. 16, no. 3, pp. 184-190.
Brown PP, Coalson JJ, Elkins RC, Hinshaw LB, Greenfield LJ. Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin. Journal of Trauma. 1976;16(3):184-190.
Brown, P. P. ; Coalson, J. J. ; Elkins, R. C. ; Hinshaw, L. B. ; Greenfield, L. J. / Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin. In: Journal of Trauma. 1976 ; Vol. 16, No. 3. pp. 184-190.
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