Hematopoietic stem cell senescence and long-term bone marrow injury

Yong Wang, Bradley A. Schulte, Daohong Zhou

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Radiotherapy and chemotherapy are commonly used for treatment of cancer. Unfortunately, these treatments frequently cause acute and/or long-term bone marrow (BM) injury that can adversely affect the quality of life and the course of treatment. Our recent studies suggest that induction of hematopoietic stem cell (HSC) senescence by ionizing radiation (IR) and certain chemotherapeutic agents may contribute to long-term BM injury by impairing the ability of HSCs to self-renew. This suggestion is in agreement with a growing body of evidence demonstrating that HSCs from Bmi-1-/- and ATM-/- mice can lose their ability to self-renew by undergoing premature senescence. Interestingly, IR and different chemotherapeutic agents may induce HSC senescence and long-term BM injury in an agent-specific manner by activation of the p53-p21 and/or p16-Rb pathways. It will be of a great interest to determine if inhibition of these pathways can ameliorate radiotherapy and chemotherapy induced long-term BM injury.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalCell Cycle
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Keywords

  • Chemotherapy
  • Hematopoietic stem cell
  • Ionizing radiation
  • Senescence

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

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