Hematological status of β-thalassemics in Madras

Natarajan Mohan, Rita Sarkar

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Although rapid technical advances have taken place in the diagnosis of β-thalassemia, still the hematological factors were found to be suitable screening test in areas like Indian subcontinent where a high prevalence of β-thalassemia trait was observed. Among various thalassemias reported in Asian Indians, β-thalassemia account for about 80% and is responsible for very high infantile mortality. Despite this, little is known about the hematological status of β-thalassemias among this ethnic group which is associated with more than five different predominant β-globin mutation with high frequency and variable number of rare ones. The present study is the first report of hematological status of β-thalassemia among this ethnic group particularly from Tamil Nadu, Southern India, who are still practising high degree of consanguinity. In the present study, a total number of 364 β-thalassemics were investigated. This includes 84 cases of homozygous β-thalasemias and the remaining 280 were heterozygotes. The hematological factors such as red cell indices, hemoglobin F and hemoglobin A2 were assessed. The results revealed a wide spectrum of hematological variables ranging from severe form as that of Mediterranean thalassemias to very mild form of anemia as that of african Negro population.

Original languageEnglish (US)
Pages (from-to)237-248
Number of pages12
JournalThe Indian Journal of Pediatrics
Issue number3
StatePublished - May 1994


  • HbA
  • HbF
  • Red cell indices
  • β-thalassemias

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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