Hemangiopericytoma: A light microscopic and ultrastructural study

Edwin W. Nunnery, Leonard B. Kahn, Robert L. Reddick, Stanley Lipper

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


An ultrastructural study of three cases of hemangiopericytoma showed cells partially or completely enveloped by well‐formed basement membrane and basement membrane‐like material. The cells exhibited prominent cytoplasmic filaments, some showing dense body formation, interdigitating cytoplasmic processes, and pinocytotic vesicles. A review of the literature revealed only 19 other cases of hemangiopericytoma studied by electron microscopy, and these included seven cases of meningeal origin (“angioblastic meningioma”). The most consistent feature seen in all but two cases was the presence of a basal lamina or basal lamina‐like material either partially or completely surrounding tumor cells and separating endothelial cells from pericytes. The light microscopic diagnosis of hemangiopericytoma is difficult, and there is a tendency to append the diagnosis to a variety of other tumors with a prominent vascular pattern in which other specific diagnoses are not immediately evident. The presence, ultrastructurally, of well‐developed basement membrane, myogenic type filaments, and pinocytotic vesicles in a tumor with light microscopic features suggestive of hemangiopericytoma would consolidate the diagnosis and usually eliminate diagnostic uncertainty. Cancer 47:906–914, 1981.

Original languageEnglish (US)
Pages (from-to)906-914
Number of pages9
Issue number5
StatePublished - Mar 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Hemangiopericytoma: A light microscopic and ultrastructural study'. Together they form a unique fingerprint.

Cite this