Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae

Debra K. Leith, Eric J. Hansen, Richard M. Wilson, Duncan C. Krause, Joel B. Baseman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A selective enrichment technique was used to isolate a hemadsorption-positive revertant of a hemadsorption-negative mutant strain of Mycoplasma pneumoniae. This hemadsorption-positive revertant was shown to have simultaneously regained both the ability to attach to neuraminidase-sensitive receptors on the tracheal ring respiratory epithelium in vitro and the ability to synthesize three virulent-strain-specific proteins which were not synthesized by the hemadsorption-negative mutant. Despite the persistence of the revertant in hamster lung tissue for 9 to 12 weeks postinfection, non cytopathology was observed. Intranasal inoculation of the revertant provided limited protection against a challenge dose of virulent M. pneumoniae.

Original languageEnglish (US)
Pages (from-to)844-850
Number of pages7
JournalUnknown Journal
Issue number2
StatePublished - 1983

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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