Hem-1, a potential membrane protein, with expression restricted to blood cells

Robert Hromas; Steven Collins; Wendy Raskind; Larry Deaven; Ken Kaushansky

doi:10.1016/0167-4781(91)90109-Y

Hem-1, a potential membrane protein, with expression restricted to blood cells

Robert Hromas, Steven Collins, Wendy Raskind, Larry Deaven, Ken Kaushansky

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Overlapping cDNAs 3.8 kb in lenght containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.

Original language	English (US)
Pages (from-to)	241-244
Number of pages	4
Journal	BBA - Gene Structure and Expression
Volume	1090
Issue number	2
DOIs	https://doi.org/10.1016/0167-4781(91)90109-Y
State	Published - Oct 8 1991
Externally published	Yes

Keywords

Chromosomal translocations
Hematopoiesis
Membrane protein
Phosphorylation site

ASJC Scopus subject areas

Genetics
Structural Biology
Biophysics
Biochemistry

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10.1016/0167-4781(91)90109-Y

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abstract = "Overlapping cDNAs 3.8 kb in lenght containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.",

keywords = "Chromosomal translocations, Hematopoiesis, Membrane protein, Phosphorylation site",

author = "Robert Hromas and Steven Collins and Wendy Raskind and Larry Deaven and Ken Kaushansky",

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doi = "10.1016/0167-4781(91)90109-Y",

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T1 - Hem-1, a potential membrane protein, with expression restricted to blood cells

AU - Hromas, Robert

AU - Collins, Steven

AU - Raskind, Wendy

AU - Deaven, Larry

AU - Kaushansky, Ken

PY - 1991/10/8

Y1 - 1991/10/8

N2 - Overlapping cDNAs 3.8 kb in lenght containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.

AB - Overlapping cDNAs 3.8 kb in lenght containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.

KW - Chromosomal translocations

KW - Hematopoiesis

KW - Membrane protein

KW - Phosphorylation site

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DO - 10.1016/0167-4781(91)90109-Y

M3 - Article

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AN - SCOPUS:0026042148

SN - 0167-4781

VL - 1090

SP - 241

EP - 244

JO - BBA - Gene Structure and Expression

JF - BBA - Gene Structure and Expression

IS - 2

ER -

Hem-1, a potential membrane protein, with expression restricted to blood cells

Abstract

Keywords

ASJC Scopus subject areas

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