Hem-1, a potential membrane protein, with expression restricted to blood cells

Robert Hromas, Steven Collins, Wendy Raskind, Larry Deaven, Ken Kaushansky

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Overlapping cDNAs 3.8 kb in lenght containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.

Original languageEnglish (US)
Pages (from-to)241-244
Number of pages4
JournalBBA - Gene Structure and Expression
Volume1090
Issue number2
DOIs
StatePublished - Oct 8 1991
Externally publishedYes

Keywords

  • Chromosomal translocations
  • Hematopoiesis
  • Membrane protein
  • Phosphorylation site

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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