Helicobacter Pylori Infection in Texas Hispanic and Non-Hispanic White Men

Implications for Gastric Cancer Risk Disparities

Dorothy Longparma, Edgar Muñoz, Susan M. Ogden, Gustavo F. Westin, Robin J Leach, Ian M. Thompson, Amelie G Ramirez

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chronic Helicobacter pylori (H. pylori) infection is a major gastric adenocarcinoma (GA) risk factor. GA disproportionately affects U.S. Hispanics compared with non-Hispanic Whites (NHWs). Since H. pylori infection studies in Hispanics are few, infection rates in Hispanic and NHW men in Bexar County were compared, and relationships with ethnicity and obesity examined. Age- and zip code-matched participants from a community-dwelling cohort were randomly selected. Sera from 284 men were analyzed by enzyme immunoassay for H. pylori antibodies. Adjusted risk ratio estimation for matched data was conducted to identify differences. Hispanics had a markedly higher prevalence of infection (30.3%) than NHWs (9.2%). Matched risk ratio (mRR) analyses revealed a strong association between H. pylori seropositivity and Hispanic ethnicity (mRR = 3.31; 95% CI [1.91, 5.73], adjusted by BMI, smoking status, and family history of cancer (mRR range = 3.28-3.89). BMI mRRs (range = 1.19-1.22) were significant in all models. In this cohort, Hispanic men had higher H. pylori infection rates than NHWs, and parallel the disproportionately higher rates of GA; obesity contributes to this higher prevalence. Future studies should address country of origin, acculturation, and other factors influencing obesity to further elucidate risk of GA in Hispanic populations.

Original languageEnglish (US)
Pages (from-to)1039-1045
Number of pages7
JournalAmerican Journal of Men's Health
Volume11
Issue number4
DOIs
StatePublished - Jul 1 2017

Fingerprint

Helicobacter Infections
Hispanic Americans
Helicobacter pylori
Stomach Neoplasms
cancer
Stomach
Adenocarcinoma
Odds Ratio
Obesity
ethnicity
Independent Living
Acculturation
country of origin
acculturation
genealogy
Infection
smoking
Immunoenzyme Techniques
Smoking
Antibodies

Keywords

  • cancer prevention
  • health inequality/disparity
  • men of color
  • quantitative research
  • risk factors

ASJC Scopus subject areas

  • Health(social science)
  • Public Health, Environmental and Occupational Health

Cite this

Helicobacter Pylori Infection in Texas Hispanic and Non-Hispanic White Men : Implications for Gastric Cancer Risk Disparities. / Longparma, Dorothy; Muñoz, Edgar; Ogden, Susan M.; Westin, Gustavo F.; Leach, Robin J; Thompson, Ian M.; Ramirez, Amelie G.

In: American Journal of Men's Health, Vol. 11, No. 4, 01.07.2017, p. 1039-1045.

Research output: Contribution to journalArticle

Longparma, Dorothy ; Muñoz, Edgar ; Ogden, Susan M. ; Westin, Gustavo F. ; Leach, Robin J ; Thompson, Ian M. ; Ramirez, Amelie G. / Helicobacter Pylori Infection in Texas Hispanic and Non-Hispanic White Men : Implications for Gastric Cancer Risk Disparities. In: American Journal of Men's Health. 2017 ; Vol. 11, No. 4. pp. 1039-1045.
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