TY - JOUR
T1 - Heightened ACE Activity and Unfavorable Consequences in COVID-19 Diabetic Subjects
AU - Sandooja, Rashi
AU - Vura, Naga Venkata Rama Krishna
AU - Morocco, Michael
N1 - Publisher Copyright:
© 2020 Rashi Sandooja et al.
PY - 2020
Y1 - 2020
N2 - Coronavirus disease-19 (COVID-19) can manifest as fever, cough, and shortness of breath and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Occasionally, these patients may present with diabetic ketoacidosis (DKA). Patients with comorbidities such as diabetes mellitus and hypertension, as well as older age groups, are known to have a more severe disease progression and poor prognosis. In this review article, we attempt to better understand the disease process in diabetics and also discuss potential mechanisms by which diabetes may play a role in disease severity. This includes the effect of diabetes on the immune response and immune dysregulation. The role of diabetes mellitus in molecular processes including augmenting Angiotensin-Converting Enzyme 2 (ACE 2) levels is also discussed as potential mechanisms to explain the grave prognosis seen in these patients.
AB - Coronavirus disease-19 (COVID-19) can manifest as fever, cough, and shortness of breath and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Occasionally, these patients may present with diabetic ketoacidosis (DKA). Patients with comorbidities such as diabetes mellitus and hypertension, as well as older age groups, are known to have a more severe disease progression and poor prognosis. In this review article, we attempt to better understand the disease process in diabetics and also discuss potential mechanisms by which diabetes may play a role in disease severity. This includes the effect of diabetes on the immune response and immune dysregulation. The role of diabetes mellitus in molecular processes including augmenting Angiotensin-Converting Enzyme 2 (ACE 2) levels is also discussed as potential mechanisms to explain the grave prognosis seen in these patients.
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U2 - 10.1155/2020/7847526
DO - 10.1155/2020/7847526
M3 - Review article
AN - SCOPUS:85089017528
SN - 1687-8337
VL - 2020
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
M1 - 7847526
ER -