Healthcare resource utilization, expenditures, and productivity in patients with asthma with and without allergies

Patrick W. Sullivan, Miguel J. Lanz, Vahram H. Ghushchyan, Abhishek Kavati, Jason LeCocq, Benjamin Ortiz, Diego J. Maselli

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective: To compare healthcare resource utilization (HCRU), healthcare expenditures, and work productivity and activity impairment within a general asthma population with persistent asthma and evidence of allergy (PA-EA) and persistent asthma with no evidence of allergy (PA-NEA). Methods: We conducted a retrospective analysis of survey responses and claims from the Observational Study of Asthma Control and Outcomes (OSACO) study. Eligible patients with persistent asthma aged ≥12 years were sent four surveys over 15 months. Regression models were used to assess the association between: (1) PA-EA (defined as a positive response to a survey question about hay fever/seasonal allergies AND ≥1 diagnostic code for atopic conditions) and HCRU and expenditures; and (2) PA-EA and Work Productivity and Activity Impairment (WPAI)-Asthma questionnaire scores (vs. PA-NEA). Results: Adjusted data showed that, vs. PA-NEA (n = 312), patients with PA-EA (n = 971) incurred 1.34-times more all-cause prescriptions (95% confidence interval [CI], 1.20–1.48), $132.79 higher prescription costs (95% CI, $22.03–243.56), and $926.11 higher all-cause total healthcare costs (95% CI, $279.67–1572.54), per 4-month period. Patients with PA-EA were 4.1% less productive while working (95% CI, 3.75–4.48%) and experienced a 6.5% reduction in all activities (95% CI, 6.11–6.88%) vs. those with PA-NEA. Conclusions: Patients with PA-EA had greater HCRU, healthcare expenditures, and lower productivity compared with those patients with PA-NEA. These results highlight the burden of atopy in patients with persistent asthma and underscore the importance of allergic endotype identification for more vigilant disease management.

Original languageEnglish (US)
Pages (from-to)959-967
Number of pages9
JournalJournal of Asthma
Issue number9
StatePublished - Sep 1 2020
Externally publishedYes


  • allergic
  • asthma
  • Economics
  • healthcare resource utilization
  • non-allergic
  • phenotypes
  • productivity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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