Health-related quality of life results in pathologic stage C prostate cancer from a Southwest Oncology Group trial comparing radical prostatectomy alone with radical prostatectomy plus radiation therapy

Carol M. Moinpour, Katherine A. Hayden, Joseph M. Unger, Ian M. Thompson, Mary W. Redman, Edith D. Canby-Hagino, Betsy A. Higgins, Jerry W. Sullivan, Dianne Lemmon, Sheila Breslin, E. David Crawford

Research output: Contribution to journalArticle

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Abstract

Purpose: To compare short- and long-term effects of adjuvant treatment versus observation after surgery on health-related quality of life (HRQL) of prostate cancer patients. Patients and Methods: The Southwest Oncology Group (SWOG) intergroup trial compared radical prostatectomy (RP) plus observation versus RP plus adjuvant radiation therapy (RT). Two-hundred seventeen of 425 therapeutic trial patients were eligible and registered to the HRQL study. Patients completed the SWOG Quality of Life Questionnaire (emotional, physical, social, and role function; general symptom status; treatment/disease-specific symptoms; and global HRQL [GHRQL]) at baseline, 6 weeks, 6 months, and annually for 5 years. Prespecified outcomes were three genitourinary symptoms (bowel function tenderness, frequent urination, and erectile dysfunction [ED]) and measures of physical and emotional function. Adjustments were made for the baseline score. Results: Patients receiving adjuvant RT reported worse bowel function (through approximately 2 years) and worse urinary function. There were no statistically significant differences for ED. GHRQL was initially worse for the RP+RT arm but improved over time and was better at the end of the period than the GHRQL reported for RP alone (treatment arm x time interaction, P = .0004). Symptom distress was significantly worse for the RP+RT arm compared with the RP alone arm, but the treatment arms did not differ with respect to other general measures of HRQL. Conclusion: The addition of RT to surgery resulted in more frequent urination, as well as early report of more bowel dysfunction, although bowel function differences disappeared over the 5-year period. The addition of RT did not negatively impact ED.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalJournal of Clinical Oncology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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Prostatectomy
Prostatic Neoplasms
Radiotherapy
Quality of Life
Erectile Dysfunction
Urination
Observation
Therapeutics
Social Adjustment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Health-related quality of life results in pathologic stage C prostate cancer from a Southwest Oncology Group trial comparing radical prostatectomy alone with radical prostatectomy plus radiation therapy. / Moinpour, Carol M.; Hayden, Katherine A.; Unger, Joseph M.; Thompson, Ian M.; Redman, Mary W.; Canby-Hagino, Edith D.; Higgins, Betsy A.; Sullivan, Jerry W.; Lemmon, Dianne; Breslin, Sheila; Crawford, E. David.

In: Journal of Clinical Oncology, Vol. 26, No. 1, 01.01.2008, p. 112-120.

Research output: Contribution to journalArticle

Moinpour, CM, Hayden, KA, Unger, JM, Thompson, IM, Redman, MW, Canby-Hagino, ED, Higgins, BA, Sullivan, JW, Lemmon, D, Breslin, S & Crawford, ED 2008, 'Health-related quality of life results in pathologic stage C prostate cancer from a Southwest Oncology Group trial comparing radical prostatectomy alone with radical prostatectomy plus radiation therapy', Journal of Clinical Oncology, vol. 26, no. 1, pp. 112-120. https://doi.org/10.1200/JCO.2006.10.4505
Moinpour, Carol M. ; Hayden, Katherine A. ; Unger, Joseph M. ; Thompson, Ian M. ; Redman, Mary W. ; Canby-Hagino, Edith D. ; Higgins, Betsy A. ; Sullivan, Jerry W. ; Lemmon, Dianne ; Breslin, Sheila ; Crawford, E. David. / Health-related quality of life results in pathologic stage C prostate cancer from a Southwest Oncology Group trial comparing radical prostatectomy alone with radical prostatectomy plus radiation therapy. In: Journal of Clinical Oncology. 2008 ; Vol. 26, No. 1. pp. 112-120.
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AU - Unger, Joseph M.

AU - Thompson, Ian M.

AU - Redman, Mary W.

AU - Canby-Hagino, Edith D.

AU - Higgins, Betsy A.

AU - Sullivan, Jerry W.

AU - Lemmon, Dianne

AU - Breslin, Sheila

AU - Crawford, E. David

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N2 - Purpose: To compare short- and long-term effects of adjuvant treatment versus observation after surgery on health-related quality of life (HRQL) of prostate cancer patients. Patients and Methods: The Southwest Oncology Group (SWOG) intergroup trial compared radical prostatectomy (RP) plus observation versus RP plus adjuvant radiation therapy (RT). Two-hundred seventeen of 425 therapeutic trial patients were eligible and registered to the HRQL study. Patients completed the SWOG Quality of Life Questionnaire (emotional, physical, social, and role function; general symptom status; treatment/disease-specific symptoms; and global HRQL [GHRQL]) at baseline, 6 weeks, 6 months, and annually for 5 years. Prespecified outcomes were three genitourinary symptoms (bowel function tenderness, frequent urination, and erectile dysfunction [ED]) and measures of physical and emotional function. Adjustments were made for the baseline score. Results: Patients receiving adjuvant RT reported worse bowel function (through approximately 2 years) and worse urinary function. There were no statistically significant differences for ED. GHRQL was initially worse for the RP+RT arm but improved over time and was better at the end of the period than the GHRQL reported for RP alone (treatment arm x time interaction, P = .0004). Symptom distress was significantly worse for the RP+RT arm compared with the RP alone arm, but the treatment arms did not differ with respect to other general measures of HRQL. Conclusion: The addition of RT to surgery resulted in more frequent urination, as well as early report of more bowel dysfunction, although bowel function differences disappeared over the 5-year period. The addition of RT did not negatively impact ED.

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