Healing of periapical lesions with complete loss of the buccal bone plate: A histologic study in the canine mandible

Thomas Von Arx, Steven Britain, David L Cochran, Robert K. Schenk, Pirkka V. Nummikoski, Daniel Buser

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This study evaluated periapical healing of induced apical lesions with concomitant loss of the buccal bone plate in a dog model using four foxhounds. In an initial surgery, pulp cavities of mandibular premolars were exposed to induce apical lesions. In the same session, the cortical bone covering the buccal root surfaces was surgically removed to simulate buccal bone loss. After radiographic confirmation of the development of apical lesions, sites were reentered for surgical treatment. Following apical and buccal debridement, root-end resection, and root-end filling, sites were subjected to three different treatment modalities: (1) flap readaptation (controls); (2) placement of a collagen membrane covering the apical defect and denuded root surface; or (3) placement of an anorganic bovine bone filler into the apical defect and onto the exposed buccal root surface, with additional application of a collagen membrane. Animals were sacrificed 7 months following the second surgery. Step sections were analyzed histometrically and morphometrically for periapical healing. Sites with membrane + filler showed a statistically significantly lower mean percentage of new bone formation within the former defect compared to both membrane-alone and control sites. No significant differences were found for tissue components deposited on the cut root face across treatment groups. Formation of a continuous thin layer of new cementum covering the exposed dentin surface and root-end filling material was a frequent finding. Analysis of the tissue regeneration on the buccal root aspect as well as the clinical periodontal parameters will be presented in a separate article.

Original languageEnglish (US)
Pages (from-to)157-167
Number of pages11
JournalInternational Journal of Periodontics and Restorative Dentistry
Volume23
Issue number2
StatePublished - Apr 2003

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Bone Plates
Zygoma
Cheek
Mandible
Canidae
Membranes
Collagen
Dental Cementum
Bicuspid
Debridement
Dentin
Osteogenesis
Regeneration
Dogs
Bone and Bones

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Healing of periapical lesions with complete loss of the buccal bone plate : A histologic study in the canine mandible. / Von Arx, Thomas; Britain, Steven; Cochran, David L; Schenk, Robert K.; Nummikoski, Pirkka V.; Buser, Daniel.

In: International Journal of Periodontics and Restorative Dentistry, Vol. 23, No. 2, 04.2003, p. 157-167.

Research output: Contribution to journalArticle

Von Arx, Thomas ; Britain, Steven ; Cochran, David L ; Schenk, Robert K. ; Nummikoski, Pirkka V. ; Buser, Daniel. / Healing of periapical lesions with complete loss of the buccal bone plate : A histologic study in the canine mandible. In: International Journal of Periodontics and Restorative Dentistry. 2003 ; Vol. 23, No. 2. pp. 157-167.
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