@article{5f5909f762e34214a3be915dc735a15e,
title = "Hdac3 is essential for the maintenance of chromatin structure and genome stability",
abstract = "Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and heterochromatin content. These defects corresponded to increases in histone H3K9,K14ac; H4K5ac; and H4K12ac in late S phase of the cell cycle, and histone deposition marks were retained in quiescent Hdac3-null cells. Liver-specific deletion of Hdac3 culminated in hepatocellular carcinoma. Whereas HDAC3 expression was downregulated in only a small number of human liver cancers, the mRNA levels of the HDAC3 cofactor NCOR1 were reduced in one-third of these cases. siRNA targeting of NCOR1 and SMRT (NCOR2) increased H4K5ac and caused DNA damage, indicating that the HDAC3/NCOR/SMRT axis is critical for maintaining chromatin structure and genomic stability.",
author = "Srividya Bhaskara and Knutson, {Sarah K.} and Guochun Jiang and Chandrasekharan, {Mahesh B.} and Wilson, {Andrew J.} and Siyuan Zheng and Ashwini Yenamandra and Kimberly Locke and Yuan, {Jia Ling} and Bonine-Summers, {Alyssa R.} and Wells, {Christina E.} and Kaiser, {Jonathan F.} and Washington, {M. Kay} and Zhongming Zhao and Wagner, {Florence F.} and Sun, {Zu Wen} and Fen Xia and Holson, {Edward B.} and Dineo Khabele and Hiebert, {Scott W.}",
note = "Funding Information: We thank all the members of the Hiebert lab for helpful discussions, reagents, and advice. We thank the Vanderbilt Imaging, Human Tissue Acquisition and Pathology, and Functional Genomics Shared Resources for services and support. We thank Drs. Nick Gilbert and James Allan for providing plasmids containing the major and minor satellite probes. This work was supported by The T.J. Martell Foundation, The Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation, National Institutes of Health grants (R01-CA64140, R01-CA77274, and R01-CA109355), and core services performed through Vanderbilt Digestive Disease Research grant NIDDK P30DK58404 and Vanderbilt-Ingram Cancer Center support grant NCI P30CA68485. S.B. was supported by a fellowship (1F32CA138091-01) from the NCI. ",
year = "2010",
month = nov,
day = "16",
doi = "10.1016/j.ccr.2010.10.022",
language = "English (US)",
volume = "18",
pages = "436--447",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",
}