HBV Therapy Following Unsuccessful Interferon Therapy: How do you see the Role for Oral Therapies?

Grace M. Chee, Fred F. Poordad

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The original therapy for chronic hepatitis B was conventional interferon, used for up to 24 weeks. This was replaced by peginterferon, which has similar efficacy, but is more convenient, with weekly dosing instead of daily or thrice weekly. Roughly one-third of HBeAg-positive patients respond with seroconversion during the treatment period. Those that respond often have baseline characteristics associated with interferon efficacy. Those that do not respond often require retreatment. This can be done with interferon, an oral antiviral or a combination of both. This chapter discusses the therapeutic options for patients who are non-responders to interferon therapy.

Original languageEnglish (US)
Title of host publicationClinical Dilemmas in Viral Liver Disease
PublisherWiley-Blackwell
Pages188-191
Number of pages4
ISBN (Print)9781405179058
DOIs
StatePublished - Mar 10 2010
Externally publishedYes

Keywords

  • Chronic hepatitis B
  • Interferon
  • Non-responder
  • Oral antiviral
  • Peginterferon
  • Retreatment

ASJC Scopus subject areas

  • Medicine(all)

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