Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

Eric E. Smith, Geert Jan Biessels, François De Guio, Frank Erik de Leeuw, Simon Duchesne, Marco Düring, Richard Frayne, M. Arfan Ikram, Eric Jouvent, Bradley J. MacIntosh, Michael J. Thrippleton, Meike W. Vernooij, Hieab Adams, Walter H. Backes, Lucia Ballerini, Sandra E. Black, Christopher Chen, Rod Corriveau, Charles DeCarli, Steven M. Greenberg & 29 others M. Edip Gurol, Michael Ingrisch, Dominic Job, Bonnie Y.K. Lam, Lenore J. Launer, Jennifer Linn, Cheryl R. McCreary, Vincent C.T. Mok, Leonardo Pantoni, G. Bruce Pike, Joel Ramirez, Yael D. Reijmer, Jose Rafael Romero, Stefan Ropele, Natalia S. Rost, Perminder S. Sachdev, Christopher J.M. Scott, Sudha Seshadri, Mukul Sharma, Steven Sourbron, Rebecca M.E. Steketee, Richard H. Swartz, Robert van Oostenbrugge, Matthias van Osch, Sanneke van Rooden, Anand Viswanathan, David Werring, Martin Dichgans, Joanna M. Wardlaw

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Abstract

Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

Original languageEnglish (US)
Pages (from-to)191-204
Number of pages14
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - Dec 1 2019

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Blood Vessels
Cerebral Small Vessel Diseases
Magnetic Resonance Imaging
Neuroimaging
Brain
Biomarkers
Telecommunications
Cerebrovascular Disorders
European Union
Neurodegenerative Diseases
Multicenter Studies
Meta-Analysis
Software
Databases
Education

Keywords

  • Cerebrovascular disease
  • Dementia
  • Magnetic resonance imaging
  • Radiology
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. / Smith, Eric E.; Biessels, Geert Jan; De Guio, François; de Leeuw, Frank Erik; Duchesne, Simon; Düring, Marco; Frayne, Richard; Ikram, M. Arfan; Jouvent, Eric; MacIntosh, Bradley J.; Thrippleton, Michael J.; Vernooij, Meike W.; Adams, Hieab; Backes, Walter H.; Ballerini, Lucia; Black, Sandra E.; Chen, Christopher; Corriveau, Rod; DeCarli, Charles; Greenberg, Steven M.; Gurol, M. Edip; Ingrisch, Michael; Job, Dominic; Lam, Bonnie Y.K.; Launer, Lenore J.; Linn, Jennifer; McCreary, Cheryl R.; Mok, Vincent C.T.; Pantoni, Leonardo; Pike, G. Bruce; Ramirez, Joel; Reijmer, Yael D.; Romero, Jose Rafael; Ropele, Stefan; Rost, Natalia S.; Sachdev, Perminder S.; Scott, Christopher J.M.; Seshadri, Sudha; Sharma, Mukul; Sourbron, Steven; Steketee, Rebecca M.E.; Swartz, Richard H.; van Oostenbrugge, Robert; van Osch, Matthias; van Rooden, Sanneke; Viswanathan, Anand; Werring, David; Dichgans, Martin; Wardlaw, Joanna M.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 191-204.

Research output: Contribution to journalShort survey

Smith, EE, Biessels, GJ, De Guio, F, de Leeuw, FE, Duchesne, S, Düring, M, Frayne, R, Ikram, MA, Jouvent, E, MacIntosh, BJ, Thrippleton, MJ, Vernooij, MW, Adams, H, Backes, WH, Ballerini, L, Black, SE, Chen, C, Corriveau, R, DeCarli, C, Greenberg, SM, Gurol, ME, Ingrisch, M, Job, D, Lam, BYK, Launer, LJ, Linn, J, McCreary, CR, Mok, VCT, Pantoni, L, Pike, GB, Ramirez, J, Reijmer, YD, Romero, JR, Ropele, S, Rost, NS, Sachdev, PS, Scott, CJM, Seshadri, S, Sharma, M, Sourbron, S, Steketee, RME, Swartz, RH, van Oostenbrugge, R, van Osch, M, van Rooden, S, Viswanathan, A, Werring, D, Dichgans, M & Wardlaw, JM 2019, 'Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 191-204. https://doi.org/10.1016/j.dadm.2019.01.002
Smith, Eric E. ; Biessels, Geert Jan ; De Guio, François ; de Leeuw, Frank Erik ; Duchesne, Simon ; Düring, Marco ; Frayne, Richard ; Ikram, M. Arfan ; Jouvent, Eric ; MacIntosh, Bradley J. ; Thrippleton, Michael J. ; Vernooij, Meike W. ; Adams, Hieab ; Backes, Walter H. ; Ballerini, Lucia ; Black, Sandra E. ; Chen, Christopher ; Corriveau, Rod ; DeCarli, Charles ; Greenberg, Steven M. ; Gurol, M. Edip ; Ingrisch, Michael ; Job, Dominic ; Lam, Bonnie Y.K. ; Launer, Lenore J. ; Linn, Jennifer ; McCreary, Cheryl R. ; Mok, Vincent C.T. ; Pantoni, Leonardo ; Pike, G. Bruce ; Ramirez, Joel ; Reijmer, Yael D. ; Romero, Jose Rafael ; Ropele, Stefan ; Rost, Natalia S. ; Sachdev, Perminder S. ; Scott, Christopher J.M. ; Seshadri, Sudha ; Sharma, Mukul ; Sourbron, Steven ; Steketee, Rebecca M.E. ; Swartz, Richard H. ; van Oostenbrugge, Robert ; van Osch, Matthias ; van Rooden, Sanneke ; Viswanathan, Anand ; Werring, David ; Dichgans, Martin ; Wardlaw, Joanna M. / Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. pp. 191-204.
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title = "Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration",
abstract = "Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.",
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TY - JOUR

T1 - Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

AU - Smith, Eric E.

AU - Biessels, Geert Jan

AU - De Guio, François

AU - de Leeuw, Frank Erik

AU - Duchesne, Simon

AU - Düring, Marco

AU - Frayne, Richard

AU - Ikram, M. Arfan

AU - Jouvent, Eric

AU - MacIntosh, Bradley J.

AU - Thrippleton, Michael J.

AU - Vernooij, Meike W.

AU - Adams, Hieab

AU - Backes, Walter H.

AU - Ballerini, Lucia

AU - Black, Sandra E.

AU - Chen, Christopher

AU - Corriveau, Rod

AU - DeCarli, Charles

AU - Greenberg, Steven M.

AU - Gurol, M. Edip

AU - Ingrisch, Michael

AU - Job, Dominic

AU - Lam, Bonnie Y.K.

AU - Launer, Lenore J.

AU - Linn, Jennifer

AU - McCreary, Cheryl R.

AU - Mok, Vincent C.T.

AU - Pantoni, Leonardo

AU - Pike, G. Bruce

AU - Ramirez, Joel

AU - Reijmer, Yael D.

AU - Romero, Jose Rafael

AU - Ropele, Stefan

AU - Rost, Natalia S.

AU - Sachdev, Perminder S.

AU - Scott, Christopher J.M.

AU - Seshadri, Sudha

AU - Sharma, Mukul

AU - Sourbron, Steven

AU - Steketee, Rebecca M.E.

AU - Swartz, Richard H.

AU - van Oostenbrugge, Robert

AU - van Osch, Matthias

AU - van Rooden, Sanneke

AU - Viswanathan, Anand

AU - Werring, David

AU - Dichgans, Martin

AU - Wardlaw, Joanna M.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

AB - Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

KW - Cerebrovascular disease

KW - Dementia

KW - Magnetic resonance imaging

KW - Radiology

KW - Stroke

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U2 - 10.1016/j.dadm.2019.01.002

DO - 10.1016/j.dadm.2019.01.002

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VL - 11

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EP - 204

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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