TY - JOUR
T1 - Hard and soft tissue evaluation of titanium dental implants and abutments with nanotubes in canines
AU - Garrett, Phillip W.
AU - Johnston, Gary W.
AU - Bosshardt, Dieter D.
AU - Jones, Archie A.
AU - Sasada, Yuya
AU - Ong, Joo L.
AU - Cochran, David L.
N1 - Funding Information:
Sonja A. Bustamante, Histology Technician (ASCP), University of Texas Health Science Center at San Antonio (UTHSCSA), is greatly acknowledged for her valuable support and surgical assistance throughout the course of this study. The authors also would like to thank Sander Hacker, Doctor of Veterinary Medicine, clinical veterinarian, and his team, Laboratory Animal Resources, UTHSCSA, for exemplary care of the animals. In addition, the authors would like to express their gratitude to Gary Johnston, Ph.D., and Nasseo, Peoria, Arizona, for funding and manufacturing the test and control implants. Dr. Johnston was employed at Nasseo at the time this study was conducted. He owns equity or stock options in Nasseo and has received financial support for research from Nasseo. Dr. Cochran has received financial support for research from Geistlich, LaunchPad Medical, Medtronic, Morita, Straumann, and Sunstar; consulting fees from LaunchPad Medical, Maxillent, Medtronic, and Straumann; and lecture fees from Medtronic, Morita, and Straumann. Dr. Cochran has also been paid as an advisor to Maxillent, Medtronic, and Straumann and owns equity or stock options in LaunchPad Medical. All other authors report no conflicts of interest related to this study.
Funding Information:
Sonja A. Bustamante, Histology Technician (ASCP), University of Texas Health Science Center at San Antonio (UTHSCSA), is greatly acknowledged for her valuable support and surgical assistance throughout the course of this study. The authors also would like to thank Sander Hacker, Doctor of Veterinary Medicine, clinical veterinarian, and his team, Laboratory Animal Resources, UTHSCSA, for exemplary care of the animals. In addition, the authors would like to express their gratitude to Gary Johnston, Ph.D., and Nasseo, Peoria, Arizona, for funding and manufacturing the test and control implants. Dr. Johnston was employed at Nasseo at the time this study was conducted. He owns equity or stock options in Nasseo and has received financial support for research from Nasseo. Dr. Cochran has received financial support for research from Geistlich, LaunchPad Medical, Medtronic, Morita, Straumann, and Sunstar; consulting fees from LaunchPad Medical, Maxillent, Medtronic, and Straumann; and lecture fees from Medtronic, Morita, and Straumann. Dr. Cochran has also been paid as an advisor to Maxillent, Medtronic, and Straumann and owns equity or stock options in LaunchPad Medical. All other authors report no conflicts of interest related to this study.
Publisher Copyright:
© 2019 American Academy of Periodontology
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Background: Little is known regarding the interaction of dental implant surface nanotubes and oral soft and hard tissues. The purpose of this study was to evaluate both histologically and radiographically the qualitative and quantitative effects of dental implant surface nanotubes on hard and soft tissue in a canine model. Methods: Three subgroups consisting of a combination of test and control implants and abutments (Group A: control implant/control abutment, Group B: control implant/test abutment: Group C: test implant/test abutment) were placed in edentulous mandibles of six large-breed canines. Implants and abutments were placed on one side at baseline, and on the opposite side of the mandible at week 10; sacrifice occurred at week 12. Quantitative and qualitative analyses were used to measure newly formed hard and soft tissues histologically and radiographically. Results: The mean radiographic change in marginal bone level from weeks 0 to 12 between implant groups was not statistically significant (P > 0.05). Mean soft tissue contact (junctional epithelium + connective tissue) for Groups A, B, and C were 2.29, 2.33, and 2.31 mm, respectively, with no statistically significant difference (P > 0.05) between the groups. All connective tissue fibers were oriented parallel to the abutment regardless of surface treatment. Conclusions: The findings of this study suggest that healing of hard and soft tissues around implants and abutments is similar when comparing grit-blasted surfaces to machined, turned surfaces with nanotubes. Both resulted in similar soft tissue contact values, as well as connective tissue fiber orientation.
AB - Background: Little is known regarding the interaction of dental implant surface nanotubes and oral soft and hard tissues. The purpose of this study was to evaluate both histologically and radiographically the qualitative and quantitative effects of dental implant surface nanotubes on hard and soft tissue in a canine model. Methods: Three subgroups consisting of a combination of test and control implants and abutments (Group A: control implant/control abutment, Group B: control implant/test abutment: Group C: test implant/test abutment) were placed in edentulous mandibles of six large-breed canines. Implants and abutments were placed on one side at baseline, and on the opposite side of the mandible at week 10; sacrifice occurred at week 12. Quantitative and qualitative analyses were used to measure newly formed hard and soft tissues histologically and radiographically. Results: The mean radiographic change in marginal bone level from weeks 0 to 12 between implant groups was not statistically significant (P > 0.05). Mean soft tissue contact (junctional epithelium + connective tissue) for Groups A, B, and C were 2.29, 2.33, and 2.31 mm, respectively, with no statistically significant difference (P > 0.05) between the groups. All connective tissue fibers were oriented parallel to the abutment regardless of surface treatment. Conclusions: The findings of this study suggest that healing of hard and soft tissues around implants and abutments is similar when comparing grit-blasted surfaces to machined, turned surfaces with nanotubes. Both resulted in similar soft tissue contact values, as well as connective tissue fiber orientation.
KW - dental implant
KW - dental implant abutment design
KW - dental implant abutment interface
KW - nanotube
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U2 - 10.1002/JPER.18-0205
DO - 10.1002/JPER.18-0205
M3 - Article
C2 - 31490010
AN - SCOPUS:85084167637
SN - 0022-3492
VL - 91
SP - 516
EP - 523
JO - Journal of periodontology
JF - Journal of periodontology
IS - 4
ER -