Haptoglobin in lung defense

F. Yang, D. J. Haile, J. J. Coalson, A. J. Ghio

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Haptoglobin (Hp) has been known to be associated with the host defence response to infection and inflammation. The biological functions of Hp can be related to its ability to bind haemoglobin or to modulate immune response. Hp is expressed at a high level in lung cells, yet its protective role(s) in the lung is not known. Using transgenic mice overexpressing Hp, we demonstrated that Hp can reduce blood-induced lung injury. Hp-mediated haemoglobin catabolism in lung cells appears to be linked to iron mobilization, and may be an efficient mechanism to reduce oxidative damage associated with haemolysis.

Original languageEnglish (US)
Pages (from-to)372-374
Number of pages3
JournalRedox Report
Volume6
Issue number6
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical

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