Abstract
The secretory mechanisms and transductal fluxes of monovalent ions and water in the rabbit parotid and submaxillary glands were investigated by using micropuncture, microperfusion, and microanalytic techniques. The primary secretory fluid obtained from the intercalated ducts of both glands was hypertonic to plasma and had the following composition: parotid: [Na], 159.7 ± 8.4; [K], 3.1 ± 1.4 mEq/liter; [Cl], 131.6 ± 6.9 mEq/liter, submaxillary: [Na], 153.0 ± 7.2; [K], 11.5 ± 3.2; [Cl], 128.1 ± 5.7 mEq/liter. The [HCO3] was measured indirectly and was 27.8 ± 3.7 in the parotid and 26.3 ± 4.1 mEq/liter in the submaxillary. The excretory ducts showed low permeability to water in the presence of strong lumen to interstitium osmotic gradients. The net transductal fluxes of Na and Cl (efflux) in the rabbit parotid were 8.37 ± 1.05 and 7.44 ± 1.55 μEq/min.g wet gland tissue while the fluxes of K (influx) varied from 0.01 to 0.20 μEq/min.g wet gland tissue at different secretory flow rates. In the submaxillary ducts, the transductal fluxes of ions were of higher capacity than in the parotid, and steady state concentrations appeared to be the only limiting factor for continuing transductal transport of ions.
| Original language | English (US) |
|---|---|
| Title of host publication | American Journal of Physiology |
| Pages | 450-455 |
| Number of pages | 6 |
| Volume | 225 |
| Edition | 2 |
| State | Published - 1973 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Handling of water and electrolytes by rabbit parotid and submaxillary glands. / Mangos, J. A.; McSherry, N. R.; Irwin, K.; Hong, R.
American Journal of Physiology. Vol. 225 2. ed. 1973. p. 450-455.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Handling of water and electrolytes by rabbit parotid and submaxillary glands
AU - Mangos, J. A.
AU - McSherry, N. R.
AU - Irwin, K.
AU - Hong, R.
PY - 1973
Y1 - 1973
N2 - The secretory mechanisms and transductal fluxes of monovalent ions and water in the rabbit parotid and submaxillary glands were investigated by using micropuncture, microperfusion, and microanalytic techniques. The primary secretory fluid obtained from the intercalated ducts of both glands was hypertonic to plasma and had the following composition: parotid: [Na], 159.7 ± 8.4; [K], 3.1 ± 1.4 mEq/liter; [Cl], 131.6 ± 6.9 mEq/liter, submaxillary: [Na], 153.0 ± 7.2; [K], 11.5 ± 3.2; [Cl], 128.1 ± 5.7 mEq/liter. The [HCO3] was measured indirectly and was 27.8 ± 3.7 in the parotid and 26.3 ± 4.1 mEq/liter in the submaxillary. The excretory ducts showed low permeability to water in the presence of strong lumen to interstitium osmotic gradients. The net transductal fluxes of Na and Cl (efflux) in the rabbit parotid were 8.37 ± 1.05 and 7.44 ± 1.55 μEq/min.g wet gland tissue while the fluxes of K (influx) varied from 0.01 to 0.20 μEq/min.g wet gland tissue at different secretory flow rates. In the submaxillary ducts, the transductal fluxes of ions were of higher capacity than in the parotid, and steady state concentrations appeared to be the only limiting factor for continuing transductal transport of ions.
AB - The secretory mechanisms and transductal fluxes of monovalent ions and water in the rabbit parotid and submaxillary glands were investigated by using micropuncture, microperfusion, and microanalytic techniques. The primary secretory fluid obtained from the intercalated ducts of both glands was hypertonic to plasma and had the following composition: parotid: [Na], 159.7 ± 8.4; [K], 3.1 ± 1.4 mEq/liter; [Cl], 131.6 ± 6.9 mEq/liter, submaxillary: [Na], 153.0 ± 7.2; [K], 11.5 ± 3.2; [Cl], 128.1 ± 5.7 mEq/liter. The [HCO3] was measured indirectly and was 27.8 ± 3.7 in the parotid and 26.3 ± 4.1 mEq/liter in the submaxillary. The excretory ducts showed low permeability to water in the presence of strong lumen to interstitium osmotic gradients. The net transductal fluxes of Na and Cl (efflux) in the rabbit parotid were 8.37 ± 1.05 and 7.44 ± 1.55 μEq/min.g wet gland tissue while the fluxes of K (influx) varied from 0.01 to 0.20 μEq/min.g wet gland tissue at different secretory flow rates. In the submaxillary ducts, the transductal fluxes of ions were of higher capacity than in the parotid, and steady state concentrations appeared to be the only limiting factor for continuing transductal transport of ions.
UR - http://www.scopus.com/inward/record.url?scp=0015881297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015881297&partnerID=8YFLogxK
M3 - Chapter
C2 - 4722409
AN - SCOPUS:0015881297
VL - 225
SP - 450
EP - 455
BT - American Journal of Physiology
ER -