HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy

Bijoy D. Thattaliyath; Carolina B. Livi; Mark E. Steinhelper; Glenn M. Toney; Anthony B. Firulli

doi:10.1016/S0006-291X(02)02297-0

HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy

Bijoy D. Thattaliyath, Carolina B. Livi, Mark E. Steinhelper, Glenn M. Toney, Anthony B. Firulli

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The HAND basic Helix-Loop-Helix (bHLH) transcription factors are essential for normal cardiac and extraembryonic development. Although highly evolutionarily conserved genes, HAND cardiac expression patterns differ across species. Mouse expression of HAND1 and HAND2 was reported absent in the adult heart. Human HAND genes are expressed in the adult heart and HAND1 expression is downregulated in cardiomyopathies. As rodent and human expression profiles are inconsistent, we re-examined expression of HAND1 and HAND2 in adult-rodent hearts. HAND1 and HAND2 are expressed in adult-rodent hearts and HAND2 is expressed in the atria. Induction of cardiac hypertrophy shows modulation of HAND expression, corresponding with observations in human cardiomyopathy. The downregulation of HAND expression observed in rodent hypertrophy and human cardiomyopathy may reflect a permissive role allowing, cardiomyocytes to reinitiate the fetal gene program and initiate the adaptive physiological changes that allow the heart to compensate (hypertrophy) for the increase in afterload.

Original language	English (US)
Pages (from-to)	870-875
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	297
Issue number	4
DOIs	https://doi.org/10.1016/S0006-291X(02)02297-0
State	Published - 2002

Keywords

Cardiac hypertrophy
HAND genes
Transcription
bHLH factors

ASJC Scopus subject areas

Molecular Biology
Biophysics
Biochemistry
Cell Biology

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10.1016/S0006-291X(02)02297-0

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title = "HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy",

abstract = "The HAND basic Helix-Loop-Helix (bHLH) transcription factors are essential for normal cardiac and extraembryonic development. Although highly evolutionarily conserved genes, HAND cardiac expression patterns differ across species. Mouse expression of HAND1 and HAND2 was reported absent in the adult heart. Human HAND genes are expressed in the adult heart and HAND1 expression is downregulated in cardiomyopathies. As rodent and human expression profiles are inconsistent, we re-examined expression of HAND1 and HAND2 in adult-rodent hearts. HAND1 and HAND2 are expressed in adult-rodent hearts and HAND2 is expressed in the atria. Induction of cardiac hypertrophy shows modulation of HAND expression, corresponding with observations in human cardiomyopathy. The downregulation of HAND expression observed in rodent hypertrophy and human cardiomyopathy may reflect a permissive role allowing, cardiomyocytes to reinitiate the fetal gene program and initiate the adaptive physiological changes that allow the heart to compensate (hypertrophy) for the increase in afterload.",

keywords = "Cardiac hypertrophy, HAND genes, Transcription, bHLH factors",

author = "Thattaliyath, {Bijoy D.} and Livi, {Carolina B.} and Steinhelper, {Mark E.} and Toney, {Glenn M.} and Firulli, {Anthony B.}",

note = "Funding Information: We thank Karen Dionne, Leanne McIlreavey, and Beth Firulli for the excellent technical assistance. This work was supported by a grant from the National Institutes of Health (R01 HLA61677-01A1) and March of Dimes Birth Defects Foundation.",

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doi = "10.1016/S0006-291X(02)02297-0",

language = "English (US)",

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AU - Livi, Carolina B.

AU - Steinhelper, Mark E.

AU - Toney, Glenn M.

AU - Firulli, Anthony B.

N1 - Funding Information: We thank Karen Dionne, Leanne McIlreavey, and Beth Firulli for the excellent technical assistance. This work was supported by a grant from the National Institutes of Health (R01 HLA61677-01A1) and March of Dimes Birth Defects Foundation.

PY - 2002

Y1 - 2002

N2 - The HAND basic Helix-Loop-Helix (bHLH) transcription factors are essential for normal cardiac and extraembryonic development. Although highly evolutionarily conserved genes, HAND cardiac expression patterns differ across species. Mouse expression of HAND1 and HAND2 was reported absent in the adult heart. Human HAND genes are expressed in the adult heart and HAND1 expression is downregulated in cardiomyopathies. As rodent and human expression profiles are inconsistent, we re-examined expression of HAND1 and HAND2 in adult-rodent hearts. HAND1 and HAND2 are expressed in adult-rodent hearts and HAND2 is expressed in the atria. Induction of cardiac hypertrophy shows modulation of HAND expression, corresponding with observations in human cardiomyopathy. The downregulation of HAND expression observed in rodent hypertrophy and human cardiomyopathy may reflect a permissive role allowing, cardiomyocytes to reinitiate the fetal gene program and initiate the adaptive physiological changes that allow the heart to compensate (hypertrophy) for the increase in afterload.

AB - The HAND basic Helix-Loop-Helix (bHLH) transcription factors are essential for normal cardiac and extraembryonic development. Although highly evolutionarily conserved genes, HAND cardiac expression patterns differ across species. Mouse expression of HAND1 and HAND2 was reported absent in the adult heart. Human HAND genes are expressed in the adult heart and HAND1 expression is downregulated in cardiomyopathies. As rodent and human expression profiles are inconsistent, we re-examined expression of HAND1 and HAND2 in adult-rodent hearts. HAND1 and HAND2 are expressed in adult-rodent hearts and HAND2 is expressed in the atria. Induction of cardiac hypertrophy shows modulation of HAND expression, corresponding with observations in human cardiomyopathy. The downregulation of HAND expression observed in rodent hypertrophy and human cardiomyopathy may reflect a permissive role allowing, cardiomyocytes to reinitiate the fetal gene program and initiate the adaptive physiological changes that allow the heart to compensate (hypertrophy) for the increase in afterload.

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HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy

Abstract

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