Abstract
Asthma is the most common chronic disease of childhood. Despite a better understanding of the disease process and its management, status asthmaticus continues to be a life-threatening event. The use of volatile inhaled anesthetics is infrequently reported as adjunctive therapy to conventional treatment of this condition. We report the use of halothane in a mechanically ventilated pediatric patient with life-threatening status asthmaticus who was admitted to the pediatric intensive care unit (PICU) after failing to respond to standard medical therapy and noninvasive positive pressure ventilation. A 12-year-old African American male was seen in the emergency department and treated with intravenous corticosteroids, beta-agonist therapy. He deteriorated rapidly and required endotracheal intubation and mechanical ventilation. Two hours later, the patient developed an acute, severe respiratory acidosis (pH = 6.97, PaCO2 = 171, PaO2 = 162, BE = 1.7). Halothane was started at 20% by using the Siemens Servo 900C anesthesia ventilator. Improvement in both arterial blood gases and exhaled tidal volume were noted 30 minutes after initiation of the anesthetic gas. The patient remained on halothane for a total of 36 hours. No adverse effects associated with the use of halothane were noted. The patient was extubated to BiPAP 16/6, FiO2 = 0.30 at 68 hours and was discharged home 5 days later.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 649-651 |
| Number of pages | 3 |
| Journal | Journal of Asthma |
| Volume | 42 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2005 |
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Keywords
- Anesthesia
- Asthma
- Halothane
- Inhaled anesthetics
- Mechanical ventilation
- Status asthmaticus
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Halothane, an effective infrequently used drug, in the treatment of pediatric status asthmaticus : A case report. / Restrepo, Ruben D.; Pettignano, Robert; DeMeuse, Patrick.
In: Journal of Asthma, Vol. 42, No. 8, 2005, p. 649-651.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Halothane, an effective infrequently used drug, in the treatment of pediatric status asthmaticus
T2 - A case report
AU - Restrepo, Ruben D.
AU - Pettignano, Robert
AU - DeMeuse, Patrick
PY - 2005
Y1 - 2005
N2 - Asthma is the most common chronic disease of childhood. Despite a better understanding of the disease process and its management, status asthmaticus continues to be a life-threatening event. The use of volatile inhaled anesthetics is infrequently reported as adjunctive therapy to conventional treatment of this condition. We report the use of halothane in a mechanically ventilated pediatric patient with life-threatening status asthmaticus who was admitted to the pediatric intensive care unit (PICU) after failing to respond to standard medical therapy and noninvasive positive pressure ventilation. A 12-year-old African American male was seen in the emergency department and treated with intravenous corticosteroids, beta-agonist therapy. He deteriorated rapidly and required endotracheal intubation and mechanical ventilation. Two hours later, the patient developed an acute, severe respiratory acidosis (pH = 6.97, PaCO2 = 171, PaO2 = 162, BE = 1.7). Halothane was started at 20% by using the Siemens Servo 900C anesthesia ventilator. Improvement in both arterial blood gases and exhaled tidal volume were noted 30 minutes after initiation of the anesthetic gas. The patient remained on halothane for a total of 36 hours. No adverse effects associated with the use of halothane were noted. The patient was extubated to BiPAP 16/6, FiO2 = 0.30 at 68 hours and was discharged home 5 days later.
AB - Asthma is the most common chronic disease of childhood. Despite a better understanding of the disease process and its management, status asthmaticus continues to be a life-threatening event. The use of volatile inhaled anesthetics is infrequently reported as adjunctive therapy to conventional treatment of this condition. We report the use of halothane in a mechanically ventilated pediatric patient with life-threatening status asthmaticus who was admitted to the pediatric intensive care unit (PICU) after failing to respond to standard medical therapy and noninvasive positive pressure ventilation. A 12-year-old African American male was seen in the emergency department and treated with intravenous corticosteroids, beta-agonist therapy. He deteriorated rapidly and required endotracheal intubation and mechanical ventilation. Two hours later, the patient developed an acute, severe respiratory acidosis (pH = 6.97, PaCO2 = 171, PaO2 = 162, BE = 1.7). Halothane was started at 20% by using the Siemens Servo 900C anesthesia ventilator. Improvement in both arterial blood gases and exhaled tidal volume were noted 30 minutes after initiation of the anesthetic gas. The patient remained on halothane for a total of 36 hours. No adverse effects associated with the use of halothane were noted. The patient was extubated to BiPAP 16/6, FiO2 = 0.30 at 68 hours and was discharged home 5 days later.
KW - Anesthesia
KW - Asthma
KW - Halothane
KW - Inhaled anesthetics
KW - Mechanical ventilation
KW - Status asthmaticus
UR - http://www.scopus.com/inward/record.url?scp=27744535430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744535430&partnerID=8YFLogxK
U2 - 10.1080/02770900500264812
DO - 10.1080/02770900500264812
M3 - Article
C2 - 16266955
AN - SCOPUS:27744535430
VL - 42
SP - 649
EP - 651
JO - Journal of Asthma
JF - Journal of Asthma
SN - 0277-0903
IS - 8
ER -