Halothane, an effective infrequently used drug, in the treatment of pediatric status asthmaticus: A case report

Ruben D. Restrepo, Robert Pettignano, Patrick DeMeuse

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Asthma is the most common chronic disease of childhood. Despite a better understanding of the disease process and its management, status asthmaticus continues to be a life-threatening event. The use of volatile inhaled anesthetics is infrequently reported as adjunctive therapy to conventional treatment of this condition. We report the use of halothane in a mechanically ventilated pediatric patient with life-threatening status asthmaticus who was admitted to the pediatric intensive care unit (PICU) after failing to respond to standard medical therapy and noninvasive positive pressure ventilation. A 12-year-old African American male was seen in the emergency department and treated with intravenous corticosteroids, beta-agonist therapy. He deteriorated rapidly and required endotracheal intubation and mechanical ventilation. Two hours later, the patient developed an acute, severe respiratory acidosis (pH = 6.97, PaCO2 = 171, PaO2 = 162, BE = 1.7). Halothane was started at 20% by using the Siemens Servo 900C anesthesia ventilator. Improvement in both arterial blood gases and exhaled tidal volume were noted 30 minutes after initiation of the anesthetic gas. The patient remained on halothane for a total of 36 hours. No adverse effects associated with the use of halothane were noted. The patient was extubated to BiPAP 16/6, FiO2 = 0.30 at 68 hours and was discharged home 5 days later.

    Original languageEnglish (US)
    Pages (from-to)649-651
    Number of pages3
    JournalJournal of Asthma
    Volume42
    Issue number8
    DOIs
    StatePublished - 2005

    Fingerprint

    Status Asthmaticus
    Halothane
    Pediatrics
    Pharmaceutical Preparations
    Respiratory Acidosis
    Inhalation Anesthetics
    Pediatric Intensive Care Units
    Intratracheal Intubation
    Positive-Pressure Respiration
    Tidal Volume
    Mechanical Ventilators
    Therapeutics
    Artificial Respiration
    African Americans
    Anesthetics
    Hospital Emergency Service
    Adrenal Cortex Hormones
    Chronic Disease
    Asthma
    Anesthesia

    Keywords

    • Anesthesia
    • Asthma
    • Halothane
    • Inhaled anesthetics
    • Mechanical ventilation
    • Status asthmaticus

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine

    Cite this

    Halothane, an effective infrequently used drug, in the treatment of pediatric status asthmaticus : A case report. / Restrepo, Ruben D.; Pettignano, Robert; DeMeuse, Patrick.

    In: Journal of Asthma, Vol. 42, No. 8, 2005, p. 649-651.

    Research output: Contribution to journalArticle

    Restrepo, Ruben D. ; Pettignano, Robert ; DeMeuse, Patrick. / Halothane, an effective infrequently used drug, in the treatment of pediatric status asthmaticus : A case report. In: Journal of Asthma. 2005 ; Vol. 42, No. 8. pp. 649-651.
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