Halogenated diarylacetylenes repress c-myc expression in cancer cells

Vitaliy M. Sviripa; Wen Zhang; Liliia M. Kril; Alice X. Liu; Yaxia Yuan; Chang Guo Zhan; Chunming Liu; David S. Watt

doi:10.1016/j.bmcl.2014.04.113

Halogenated diarylacetylenes repress c-myc expression in cancer cells

Vitaliy M. Sviripa
, Wen Zhang
, Liliia M. Kril
, Alice X. Liu
, Yaxia Yuan
, Chang Guo Zhan
, Chunming Liu
, David S. Watt

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.

Original language	English (US)
Pages (from-to)	3638-3640
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2014.04.113
State	Published - Aug 1 2014
Externally published	Yes

Keywords

Antineoplastic agents
Colon cancer
Diarylacetylenes
c-myc

ASJC Scopus subject areas

Drug Discovery
Molecular Medicine
Molecular Biology
Biochemistry
Clinical Biochemistry
Pharmaceutical Science
Organic Chemistry

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10.1016/j.bmcl.2014.04.113

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@article{2652cb32cb424997914b465fcb38798c,

title = "Halogenated diarylacetylenes repress c-myc expression in cancer cells",

abstract = "Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.",

keywords = "Antineoplastic agents, Colon cancer, Diarylacetylenes, c-myc",

author = "Sviripa, \{Vitaliy M.\} and Wen Zhang and Kril, \{Liliia M.\} and Liu, \{Alice X.\} and Yaxia Yuan and Zhan, \{Chang Guo\} and Chunming Liu and Watt, \{David S.\}",

note = "Funding Information: C.L. and D.S.W. were supported by R21 CA139359 and CA172379 from the NIH . C.G.Z. was supported by CHE-1111761 from the NSF . D.S.W. was supported by the Office of the Dean of the College of Medicine and by NIH Grant Number P20 RR020171 from the National Institute of General Medical Sciences to L. Hersh, P.I. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH or the NIGMS. ",

year = "2014",

month = aug,

day = "1",

doi = "10.1016/j.bmcl.2014.04.113",

language = "English (US)",

volume = "24",

pages = "3638--3640",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "15",

}

TY - JOUR

T1 - Halogenated diarylacetylenes repress c-myc expression in cancer cells

AU - Sviripa, Vitaliy M.

AU - Zhang, Wen

AU - Kril, Liliia M.

AU - Liu, Alice X.

AU - Yuan, Yaxia

AU - Zhan, Chang Guo

AU - Liu, Chunming

AU - Watt, David S.

N1 - Funding Information: C.L. and D.S.W. were supported by R21 CA139359 and CA172379 from the NIH . C.G.Z. was supported by CHE-1111761 from the NSF . D.S.W. was supported by the Office of the Dean of the College of Medicine and by NIH Grant Number P20 RR020171 from the National Institute of General Medical Sciences to L. Hersh, P.I. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH or the NIGMS.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.

AB - Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.

KW - Antineoplastic agents

KW - Colon cancer

KW - Diarylacetylenes

KW - c-myc

UR - https://www.scopus.com/pages/publications/84904057693

UR - https://www.scopus.com/pages/publications/84904057693#tab=citedBy

U2 - 10.1016/j.bmcl.2014.04.113

DO - 10.1016/j.bmcl.2014.04.113

M3 - Article

C2 - 24930834

AN - SCOPUS:84904057693

SN - 0960-894X

VL - 24

SP - 3638

EP - 3640

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Halogenated diarylacetylenes repress c-myc expression in cancer cells

Abstract

Keywords

ASJC Scopus subject areas

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