Halogenated diarylacetylenes repress c-myc expression in cancer cells

Vitaliy M. Sviripa, Wen Zhang, Liliia M. Kril, Alice X. Liu, Yaxia Yuan, Chang Guo Zhan, Chunming Liu, David S. Watt

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.

Original languageEnglish (US)
Pages (from-to)3638-3640
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number15
DOIs
StatePublished - Aug 1 2014
Externally publishedYes

Keywords

  • Antineoplastic agents
  • c-myc
  • Colon cancer
  • Diarylacetylenes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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