Halicylindrosides, antifungal and cytotoxic cerebrosides from the marine sponge Halichondria cylindrata

Hong yu Li; Shigeki Matsunaga; Nobuhiro Fusetani

doi:10.1016/0040-4020(94)01097-J

Halicylindrosides, antifungal and cytotoxic cerebrosides from the marine sponge Halichondria cylindrata

Hong yu Li, Shigeki Matsunaga, Nobuhiro Fusetani

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Abstract

Ten new glycosphingolipids, halicylindrosides A₁-A₄ (1-4) and B₁-B₆ (5-10) have been isolated from the Japanese marine sponge Halichondria cylindrata. Their structures were determined by spectroscopic and chemical methods. These cerebrosides were moderately antifungal against Mortierella remanniana, and cytotoxic against P388 murine leukemia cells.

Original language	English (US)
Pages (from-to)	2273-2280
Number of pages	8
Journal	Tetrahedron
Volume	51
Issue number	8
DOIs	https://doi.org/10.1016/0040-4020(94)01097-J
State	Published - Feb 20 1995
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "Ten new glycosphingolipids, halicylindrosides A1-A4 (1-4) and B1-B6 (5-10) have been isolated from the Japanese marine sponge Halichondria cylindrata. Their structures were determined by spectroscopic and chemical methods. These cerebrosides were moderately antifungal against Mortierella remanniana, and cytotoxic against P388 murine leukemia cells.",

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AU - Li, Hong yu

AU - Matsunaga, Shigeki

AU - Fusetani, Nobuhiro

PY - 1995/2/20

Y1 - 1995/2/20

N2 - Ten new glycosphingolipids, halicylindrosides A1-A4 (1-4) and B1-B6 (5-10) have been isolated from the Japanese marine sponge Halichondria cylindrata. Their structures were determined by spectroscopic and chemical methods. These cerebrosides were moderately antifungal against Mortierella remanniana, and cytotoxic against P388 murine leukemia cells.

AB - Ten new glycosphingolipids, halicylindrosides A1-A4 (1-4) and B1-B6 (5-10) have been isolated from the Japanese marine sponge Halichondria cylindrata. Their structures were determined by spectroscopic and chemical methods. These cerebrosides were moderately antifungal against Mortierella remanniana, and cytotoxic against P388 murine leukemia cells.

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Halicylindrosides, antifungal and cytotoxic cerebrosides from the marine sponge Halichondria cylindrata

Abstract

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