Haemoglobin and serum iron responses to periodic intravenous iron dextran infusions during maintenance haemodialysis

W. K. Stewart, L. W. Fleming, A. M.M. Shepherd

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Patients with chronic renal failure who were on maintenance haemodialysis, were given monthly 600 mg iron intravenously as iron dextran complex to a body replacement total of 5-6 g iron. Those patients who had been on maintenance haemodialysis for a long period and had received numerous blood transfusions failed to show a rise in haemoglobin levels. Those patients who received iron from the commencement of maintenance dialysis, and who had not received blood transfusions, showed a significant increase in haemoglobin concentrations which has been maintained for more than 18 months after iron therapy ceased, despite a concurrent decrease in serum iron concentrations. Pretreatment and post treatment levels of serum iron are not of predictive value for the success of iron treatment, neither for the haemoglobin nor the serum iron response. A body replacement dose of iron given intravenously over a year benefits the majority of patients on maintenance haemodialysis and is recommended for the treatment of their anaemia.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalNephron
Volume17
Issue number2
DOIs
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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