Haemodynamics and myocardial function after sotalol

I. Hutton, A. R. Lorimer, W. S. Hillis, D. McCall, J. M. Reid, T. D.V. Lawrie

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The cardiovascular effects of the beta-adrenergic blocking agent, sotalol, have been assessed in a group of patients with heart disease. There was a significant reduction in heart rate and cardiac output, but stroke volume was unchanged. Systemic arterial and pulmonary artery pressures were not significantly altered. Indices of mryocardial function (dp/dt max and V max) were also significantly reduced. Though previous studies have reported that sotalol is devoid of myocardial depression associated with other beta-adrenergic blocking drugs, these results suggest that sotalol has both a negative chronotropic and a lesser negative inotropic action.

Original languageEnglish (US)
Pages (from-to)787-790
Number of pages4
JournalHeart
Volume34
Issue number8
DOIs
StatePublished - 1972

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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