The cardiovascular effects of the beta-adrenergic blocking agent, sotalol, have been assessed in a group of patients with heart disease. There was a significant reduction in heart rate and cardiac output, but stroke volume was unchanged. Systemic arterial and pulmonary artery pressures were not significantly altered. Indices of mryocardial function (dp/dt max and V max) were also significantly reduced. Though previous studies have reported that sotalol is devoid of myocardial depression associated with other beta-adrenergic blocking drugs, these results suggest that sotalol has both a negative chronotropic and a lesser negative inotropic action.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine