H2O2 induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin

Ewa Sewerynek, Burkhard Poeggeler, Daniela Melchiorri, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Melatonin protection against H2O2-induced lipid peroxidation in brain homogenates was measured in vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) was assayed in brain homogenates as an index of induced membrane oxidative damage. Brain homogenates were co-incubated with H2O2 alone or in combination with melatonin. Brain MDA + 4-HDA increased after H202 (0.1-5 mM) with the effect being both concentration- and time-dependent. Melatonin (0.1-5 mM) protected against H2O2-induced lipid peroxidation of brain homogenates in a concentration-dependent manner.

Original languageEnglish (US)
Pages (from-to)203-205
Number of pages3
JournalNeuroscience Letters
Volume195
Issue number3
DOIs
StatePublished - Aug 11 1995

Keywords

  • Brain
  • HO
  • Hydroxyl radical
  • Lipid peroxidation
  • Melatonin

ASJC Scopus subject areas

  • Neuroscience(all)

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