TY - JOUR
T1 - Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome
AU - Glueck, Charles J.
AU - Salehi, Marzieh
AU - Sieve, Luann
AU - Wang, Ping
N1 - Funding Information:
Supported by the Jewish Hospital Lipoprotein Research Fund and by the Medical Research Council of the Jewish Hospital.
PY - 2006/5
Y1 - 2006/5
N2 - Objectives: To test the hypothesis that metformin during lactation versus formula feeding would have no adverse effects on infants' growth, motor-social development, or intercurrent illness. Study design: Growth, motor-social development, and illness requiring a pediatrician visit were assessed in 61 nursing infants (21 male, 40 female) and 50 formula-fed infants (19 male, 31 female) born to 92 mothers with polycystic ovary syndrome (PCOS) taking a median of 2.55 g metformin per day throughout pregnancy and lactation. Results: Within sex, at 3 and 6 months of age, weight, height, and motor-social development did not differ (p ≥.06) between breast- and formula-fed infants. No infants had retardation of growth, motor, or social development. Intercurrent illnesses did not differ. Conclusions: Metformin during lactation appears to be safe and effective in the first 6 months of infancy.
AB - Objectives: To test the hypothesis that metformin during lactation versus formula feeding would have no adverse effects on infants' growth, motor-social development, or intercurrent illness. Study design: Growth, motor-social development, and illness requiring a pediatrician visit were assessed in 61 nursing infants (21 male, 40 female) and 50 formula-fed infants (19 male, 31 female) born to 92 mothers with polycystic ovary syndrome (PCOS) taking a median of 2.55 g metformin per day throughout pregnancy and lactation. Results: Within sex, at 3 and 6 months of age, weight, height, and motor-social development did not differ (p ≥.06) between breast- and formula-fed infants. No infants had retardation of growth, motor, or social development. Intercurrent illnesses did not differ. Conclusions: Metformin during lactation appears to be safe and effective in the first 6 months of infancy.
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U2 - 10.1016/j.jpeds.2006.01.011
DO - 10.1016/j.jpeds.2006.01.011
M3 - Article
C2 - 16737874
AN - SCOPUS:33646843769
SN - 0022-3476
VL - 148
SP - 628-632.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -