Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome

Charles J. Glueck, Marzieh Salehi, Luann Sieve, Ping Wang

Research output: Contribution to journalArticle

37 Scopus citations


Objectives: To test the hypothesis that metformin during lactation versus formula feeding would have no adverse effects on infants' growth, motor-social development, or intercurrent illness. Study design: Growth, motor-social development, and illness requiring a pediatrician visit were assessed in 61 nursing infants (21 male, 40 female) and 50 formula-fed infants (19 male, 31 female) born to 92 mothers with polycystic ovary syndrome (PCOS) taking a median of 2.55 g metformin per day throughout pregnancy and lactation. Results: Within sex, at 3 and 6 months of age, weight, height, and motor-social development did not differ (p ≥.06) between breast- and formula-fed infants. No infants had retardation of growth, motor, or social development. Intercurrent illnesses did not differ. Conclusions: Metformin during lactation appears to be safe and effective in the first 6 months of infancy.

Original languageEnglish (US)
Pages (from-to)628-632.e2
JournalJournal of Pediatrics
Issue number5
Publication statusPublished - May 2006


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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