Growth factors and heme oxygenase-1: Perspectives in physiology and pathophysiology

Nathalie S Hill-kapturczak, Tambi Jarmi, Anupam Agarwal

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Growth factors are mediators of both normal homeostasis and pathophysiology through their effects on various cellular processes. Similarly, heme oxygenase-1 (HO-1) has a role in maintaining physiologic equilibrium, by which it can either alleviate or exacerbate disease, depending on several considerations, including amount, timing, and location of expression, as well as the disease setting. Thus, the synthesis and activities of growth factors and HO-1 are intricately regulated. Interestingly, several growth factors induce HO-1, and, conversely, HO-1 can regulate the expression of some growth factors. This review focuses on the influence of growth factors and HO-1 and potential physiologic effects of the growth factor(s)-HO-1 interaction.

Original languageEnglish (US)
Pages (from-to)2197-2207
Number of pages11
JournalAntioxidants and Redox Signaling
Volume9
Issue number12
DOIs
StatePublished - Oct 1 2007
Externally publishedYes

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Heme Oxygenase-1
Physiology
Intercellular Signaling Peptides and Proteins
Homeostasis

ASJC Scopus subject areas

  • Biochemistry

Cite this

Growth factors and heme oxygenase-1 : Perspectives in physiology and pathophysiology. / Hill-kapturczak, Nathalie S; Jarmi, Tambi; Agarwal, Anupam.

In: Antioxidants and Redox Signaling, Vol. 9, No. 12, 01.10.2007, p. 2197-2207.

Research output: Contribution to journalArticle

Hill-kapturczak, Nathalie S ; Jarmi, Tambi ; Agarwal, Anupam. / Growth factors and heme oxygenase-1 : Perspectives in physiology and pathophysiology. In: Antioxidants and Redox Signaling. 2007 ; Vol. 9, No. 12. pp. 2197-2207.
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