Growth factors and heme oxygenase-1: Perspectives in physiology and pathophysiology

Nathalie Hill-Kapturczak, Tambi Jarmi, Anupam Agarwal

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Growth factors are mediators of both normal homeostasis and pathophysiology through their effects on various cellular processes. Similarly, heme oxygenase-1 (HO-1) has a role in maintaining physiologic equilibrium, by which it can either alleviate or exacerbate disease, depending on several considerations, including amount, timing, and location of expression, as well as the disease setting. Thus, the synthesis and activities of growth factors and HO-1 are intricately regulated. Interestingly, several growth factors induce HO-1, and, conversely, HO-1 can regulate the expression of some growth factors. This review focuses on the influence of growth factors and HO-1 and potential physiologic effects of the growth factor(s)-HO-1 interaction.

Original languageEnglish (US)
Pages (from-to)2197-2207
Number of pages11
JournalAntioxidants and Redox Signaling
Volume9
Issue number12
DOIs
StatePublished - Oct 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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