Growth and characterization of childhood rhabdomyosarcomas as xenografts

J. A. Houghton, P. J. Houghton, B. L. Webber

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Eleven surgical specimens of childhood rhabdomyosarcoma (RMS), two bone marrow samples, and cells from ascitic fluid from 1 patient were implanted sc into immune-deprived inbred CBA/CaJ mice. From these, seven lines of RMS were obtained as xenografts, each retaining the histologic characteristics of the tumor of origin and human lactate dehydrogenase isozymes; these represented 6 of the 11 surgical specimens, whereas one line originated from the transplanted cells from ascitic fluid. It was concluded that childhood RMS has a fairly high frequency of heterotransplantability in this system and that such a laboratory model may prove useful in the development of new therapeutic regimens in this disease.

Original languageEnglish (US)
Pages (from-to)437-443
Number of pages7
JournalJournal of the National Cancer Institute
Volume68
Issue number3
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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