Gray matter prefrontal changes in type 2 diabetes detected using MRI

Anand Kumar, Ebrahim Haroon, Christine Darwin, Daniel Pham, Olusola Ajilore, Genevieve Rodriguez, Jim Mintz

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Purpose: To examine the volumes of the gray and white matter both globally and regionally in patients diagnosed with type 2 diabetes and controls. Materials and Methods: Our samples were comprised of 26 patients with type 2 diabetes, 26 patients with diabetes and major depressive disorder, and 25 nondiabetic, nondepressed control subjects. All subjects were studied cross-sectionally on a 1.5 T scanner and were recruited from medicine/diabetes clinics. Both gray and white matter volumes were estimated using an automated method, and the prefrontal areas studied included the anterior cingulate, the gyrus rectus, and the orbitofrontal regions. Results: Patients with diabetes, both with and without depression, had smaller total brain gray matter volumes when compared with the control subjects after controlling for age, intracranial volume, and years of education. This group also had smaller gray matter volumes in the anterior cingulate and orbitofrontal regions when compared with the controls after additionally controlling for total gray matter volume. The depressed and nondepressed diabetic groups did not differ on any neuroimaging measure. Cerebrovascular risk factors correlated negatively with gray matter volumes. Conclusion: The findings indicate that type 2 diabetes is associated with specific neuroanatomical abnormalities in the prefrontal gray matter. Vascular disease might contribute to the findings observed in our sample. These observations have implications for the behavioral sequelae of diabetes.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume27
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Gyrus Cinguli
Prefrontal Cortex
Major Depressive Disorder
Gray Matter
Vascular Diseases
Neuroimaging
Medicine
Depression
Education
Brain

Keywords

  • Gray matter changes
  • MRI
  • Neuroanatomy
  • Prefrontal
  • Type 2 diabetes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Gray matter prefrontal changes in type 2 diabetes detected using MRI. / Kumar, Anand; Haroon, Ebrahim; Darwin, Christine; Pham, Daniel; Ajilore, Olusola; Rodriguez, Genevieve; Mintz, Jim.

In: Journal of Magnetic Resonance Imaging, Vol. 27, No. 1, 01.2008, p. 14-19.

Research output: Contribution to journalArticle

Kumar, A, Haroon, E, Darwin, C, Pham, D, Ajilore, O, Rodriguez, G & Mintz, J 2008, 'Gray matter prefrontal changes in type 2 diabetes detected using MRI', Journal of Magnetic Resonance Imaging, vol. 27, no. 1, pp. 14-19. https://doi.org/10.1002/jmri.21224
Kumar A, Haroon E, Darwin C, Pham D, Ajilore O, Rodriguez G et al. Gray matter prefrontal changes in type 2 diabetes detected using MRI. Journal of Magnetic Resonance Imaging. 2008 Jan;27(1):14-19. https://doi.org/10.1002/jmri.21224
Kumar, Anand ; Haroon, Ebrahim ; Darwin, Christine ; Pham, Daniel ; Ajilore, Olusola ; Rodriguez, Genevieve ; Mintz, Jim. / Gray matter prefrontal changes in type 2 diabetes detected using MRI. In: Journal of Magnetic Resonance Imaging. 2008 ; Vol. 27, No. 1. pp. 14-19.
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