Granulomatous pneumocystis carinii pneumonia in three patients with the acquired immune deficiency syndrome

I. J. Bleiweiss, J. S. Jagirdar, M. J. Klein, J. L. Siegel, D. J. Krellenstein, A. R. Gribetz, J. A. Strauchen

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Pneumocystis carinii pneumonia is a frequent manifestation of the acquired immune deficiency syndrome (AIDS). It usually presents radiologically as diffuse bilateral infiltrates and histologically as a foamy, eosinophilic intra-alveolar exudate containing the organisms' cysts. We recently studied two rare cases of P carinii pneumonia presenting as pulmonary nodules on chest x-ray films in two patients with AIDS. The corresponding histologies were a combination of the usual intra-alveolar pattern, with an alveolar and interstitial granulomatous appearance. Pneumocystis carinii was present was present in both areas and was the only organism found in the tissues examined. A third case presented with the more common radiographic appearance but also had a granulomatous histology. We conclude that P carinii pneumonia should be considered in the differential diagnosis of pulmonary nodules in immunocompromised patients and that pathologists should be aware of the possibility of a granulomatous reaction to this organism.

Original languageEnglish (US)
Pages (from-to)580-583
Number of pages4
JournalChest
Volume94
Issue number3
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Granulomatous pneumocystis carinii pneumonia in three patients with the acquired immune deficiency syndrome'. Together they form a unique fingerprint.

  • Cite this

    Bleiweiss, I. J., Jagirdar, J. S., Klein, M. J., Siegel, J. L., Krellenstein, D. J., Gribetz, A. R., & Strauchen, J. A. (1988). Granulomatous pneumocystis carinii pneumonia in three patients with the acquired immune deficiency syndrome. Chest, 94(3), 580-583. https://doi.org/10.1378/chest.94.3.580