Granulated 'marginal cell layer' in the rat anterior pituitary gland

Tsuyoshi Soji, Takashi Yashiro, Damon C. Herbert

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A granulated 'marginal layer cell' was observed in the lining of Rathke's residual pouch of 5 and 10 day-old rat anterior pituitary glands. Immunohistochemistry was not employed to identify the precise function of these cells. However, the cytological characteristics of nearly all of the cells indicated that they resembled GH-secreting cells, with a few displaying morphological features of corticotrophs. In pituitary glands of 5-20 day-old rats, both ends of Rathke's residual pouch extended into the pars distalis at the site of transitional zone of this lobe and of the pars intermedia. The cells within the 'invading' residual pouch contained numerous microvilli. In the middle portion of the residual pouch, cavities lined by 'marginal layer cells' had numerous microvilli and were adjoined by junctional complexes. In the adult rat pituitary gland, there were no granulated cells in the 'marginal cell layer' and no invasion of the residual pouch into the anterior lobe. From these data the possible source of the follicle and of the folliculo-stellate cells in the anterior pituitary of the rat is proposed.

Original languageEnglish (US)
Pages (from-to)849-856
Number of pages8
JournalTissue and Cell
Volume21
Issue number6
DOIs
StatePublished - 1989

Keywords

  • electron microscopy
  • marginal cell layer
  • Pituitary gland
  • rat

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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